2. Gene
  3. MAPK8IP2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

MAPK8IP2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶 8 相互作用蛋白 2

种属: Homo sapiens

同用名: IB2; IB-2; JIP2; PRKM8IPL

基因 ID: 23542 | 基因类型: protein coding

关于 MAPK8IP2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,600,793-50,613,978 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 11 paralogues. Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues.

功能概要

该基因编码一种支架蛋白，该蛋白被认为参与了 c-Jun 氨基末端激酶信号通路的调节。这种蛋白质已被证明与 MAPK8/JNK1 和 MAP2K7/MKK7 激酶相互作用并调节其活性。[RefSeq 提供，2017 年 6 月]

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]

MAPK8IP2 基因产物(1)

mRNA Protein Name
NM_012324.6 NP_036456.1 C-Jun-amino-terminal kinase-interacting protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP-kinase scaffold activity IDA
IDA: 通过直接分析推断
10756100 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
12244047 GOA
enables protein kinase activator activity IGI
IGI: 通过遗传相互作用推断
12244047 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
10490659 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within MAPK cascade IDA
IDA: 通过直接分析推断
12244047 GOA
involved in negative regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
10756100 GOA
involved in regulation of JNK cascade IDA
IDA: 通过直接分析推断
10490659 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10490659 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK8IP2 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (610 - 659)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (682 - 812)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
蛋白主名 其他名称

C-Jun-amino-terminal kinase-interacting protein 2

JNK MAP kinase scaffold protein 2

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan
Hemorrhagic Cystitis
Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion
X-Linked Cerebellar Ataxia
Theileriasis

Theileriosis

Infection By Theileria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAPK8IP2 RGD RGD:1309727
Felis catus MAPK8IP2 VGNC VGNC:109516
Mus musculus MAPK8IP2 MGD MGI:1926555
Canis familiaris MAPK8IP2 VGNC VGNC:43002
Bos taurus MAPK8IP2 VGNC VGNC:31225
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