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  2. COLEC10 - collectin subfamily member 10 Gene

COLEC10 - collectin subfamily member 10 Gene

中文名称:收集素亚科成员 10

种属: Homo sapiens

同用名: 3MC3; CLL1; CL-10; CL-34

基因 ID: 10584 | 基因类型: protein coding

关于 COLEC10

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:118,952,263-119,108,455 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 17.0), placenta (RPKM 3.8) and 2 other tissues.

功能概要

该基因编码 C-凝集素家族的成员,即具有胶原蛋白样序列和碳水化合物识别域的蛋白质。该家族的其他成员是分泌蛋白,与微生物上的碳水化合物抗原结合,促进它们的识别和去除。该基因产物是一种胞质蛋白,这一特征表明它可能具有与其他 C-凝集素不同的生物学功能。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The Other members of this family are secreted proteins and bind to carbohydrate antigens on Microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than Other C-lectins. [provided by RefSeq, Jul 2008]

COLEC10 基因产物(2)

mRNA Protein Name
NM_001324095.2 NP_001311024.1 collectin-10 isoform 2
NM_006438.5 NP_006429.2 collectin-10 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemoattractant activity IDA
IDA: 通过直接分析推断
28301481 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24174618 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in complement activation, lectin pathway IDA
IDA: 通过直接分析推断
24174618 GOA
involved in cranial skeletal system development IMP
IMP: 通过突变表型推断
28301481 GOA
involved in positive regulation of opsonization IDA
IDA: 通过直接分析推断
24174618 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
24174618 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10224141 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
28301481 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

COLEC10 蛋白结构

Collagen

Collagen: Collagen triple helix repeat (20 copies) (46 - 95)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (62 - 117)

Lectin_C

Lectin_C: Lectin C-type domain (166 - 272)

  • 0
  • 100
  • 200
  • 277 a.a.
蛋白主名 其他名称

collectin-10

collectin liver 1

COLEC10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
COLEC10 Q9Y6Z7 COLEC11 Homo sapiens Q9BWP8
ELISA
24174618
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
3mc Syndrome 3

3MC3

Malpuech Facial Clefting Syndrome

Facial Clefting Syndrome, Gypsy Type

Malpuech Facial Clefting Syndrome, Formerly

Facial Clefting Syndrome Gypsy Type

Malpuech Syndrome

3mc Syndrome, Type 3

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome

Malpuech Facial Clefting Syndrome

Oculopalatoskeletal Syndrome

Carnevale Syndrome

Michels Syndrome

Malpuech-Michels-Mingarelli-Carnevale Syndrome

Carnevale-Krajewska-Fischetto Syndrome

Craniosynostosis With Lid Anomalies

Malpuech Syndrome

Mingarelli Syndrome

Oculo-Skeletal-Abdominal Syndrome

Osa Syndrome

Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

Ptosis-Strabismus-Rectus Abdominis Diastasis

3mc Syndrome 2

3MC2

Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

Oculo-Skeletal-Abdominal Syndrome

Osa Syndrome

Carnevale Syndrome

Carnevale Syndrome, Formerly

Carnevale Krajewska Fischetto Syndrome

3mc Syndrome, Type 2

3mc Syndrome 1

Oculopalatoskeletal Syndrome

3MC1

Craniosynostosis With Lid Anomalies

Michels Syndrome, Formerly

Michels Syndrome

3mc Syndrome, Type 1

Blepharophimosis
Properdin Deficiency, X-Linked

Properdin Deficiency

PFD

CFPD

Properdin P Factor Deficiency

Complement Factor Properdin Deficiency

X-Linked Properdin Deficiency

Properdin Deficiency, Type I

Properdin Deficiency, Type 1

Properdin Deficiency Disease

Van Maldergem Syndrome 1

Cerebrofacioarticular Syndrome

VMLDS1

Van Maldergem Syndrome

Cerebro-Facio-Articular Syndrome

Van Maldergem Wetzburger Verloes Syndrome

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus COLEC10 RGD RGD:1307149
Felis catus COLEC10 VGNC VGNC:81642
Canis familiaris COLEC10 VGNC VGNC:39488
Mus musculus COLEC10 MGD MGI:3606482
Bos taurus COLEC10 VGNC VGNC:53852
Macaca mulatta COLEC10 VGNC VGNC:71309
Macaca fascicularis COLEC10 NCBI NCBI:102117541
Others COLEC10 NCBI