2. Gene
  3. TRIM16 - tripartite motif containing 16 Gene

TRIM16 - tripartite motif containing 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 16

种属: Homo sapiens

同用名: EBBP

基因 ID: 10626 | 基因类型: protein coding

关于 TRIM16

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,627,966-15,684,311 (from NCBI)

This gene has 26 transcripts (splice variants), 225 orthologues and 80 paralogues. Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues.

功能概要

由该基因编码的蛋白质是一个三联基序 (TRIM) 家族成员，包含两个 B 盒结构域和一个卷曲螺旋区域，这是 B 盒锌指蛋白家族的特征。虽然它缺少在其他 TRIM 蛋白中发现的 RING 结构域，但编码的蛋白可以与其他 TRIM 蛋白同二聚化或异二聚化，并具有 E3 泛素连接酶活性。该基因也是一种肿瘤抑制基因，并参与分泌性自噬。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in Other TRIM proteins, the encoded protein can homodimerize or heterodimerize with Other TRIM proteins and has E3 ubiquitin Ligase activity. This gene is also a tumor suppressor and is involved in secretory Autophagy. [provided by RefSeq, Jan 2017]

TRIM16 基因产物(8)

mRNA Protein Name
NM_001348119.1 NP_001335048.1 tripartite motif-containing protein 16 isoform a
NM_001348120.1 NP_001335049.1 tripartite motif-containing protein 16 isoform a
NM_001348121.1 NP_001335050.1 tripartite motif-containing protein 16 isoform b
NM_001348122.1 NP_001335051.1 tripartite motif-containing protein 16 isoform b
NM_001348124.1 NP_001335053.1 tripartite motif-containing protein 16 isoform c
NM_001348125.1 NP_001335054.1 tripartite motif-containing protein 16 isoform c
NM_001348126.1 NP_001335055.1 tripartite motif-containing protein 16 isoform d
NM_006470.4 NP_006461.3 tripartite motif-containing protein 16 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
16636064 GOA
enables NACHT domain binding IPI
IPI: 通过物理相互作用推断
16575408 GOA
enables interleukin-1 binding IPI
IPI: 通过物理相互作用推断
16575408 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16575408 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16636064 GOA
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16575408 GOA
involved in positive regulation of keratinocyte differentiation IDA
IDA: 通过直接分析推断
11919186 GOA
involved in positive regulation of retinoic acid receptor signaling pathway IDA
IDA: 通过直接分析推断
16636064 GOA
involved in response to growth hormone IDA
IDA: 通过直接分析推断
11919186 GOA
involved in response to organophosphorus IEP
IEP: 通过表达模式推断
16079077 GOA
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
16636064 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
16636064 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9817599 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM16 蛋白结构

zf-B_box

zf-B_box: B-box zinc finger (129 - 165)

PRY

PRY: SPRY-associated domain (375 - 423)

SPRY

SPRY: SPRY domain (427 - 549)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 16

E3 ubiquitin-protein ligase TRIM16

TRIM16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM16 O95361 TRIM16L Homo sapiens Q309B1
Anti Tag CoIP
33961781
种属内
TRIM16 O95361 TRIM16L Homo sapiens Q309B1
Anti Tag CoIP
28514442
种属内
TRIM16 O95361 VIM Homo sapiens P08670
Anti Bait CoIP
20729920
种属内
TRIM16 O95361 VIM Homo sapiens P08670
Confocal
20729920
种属内
TRIM16 O95361 E2F1 Homo sapiens Q01094
Anti Tag CoIP
20729920
种属内
TRIM16 O95361 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15024 TRIM16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM16 RGD RGD:1309749
Bos taurus TRIM16 VGNC VGNC:107280
Mus musculus TRIM16 MGD MGI:2137356
Others TRIM16 NCBI
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