1. Gene
  2. GNA13 - G protein subunit alpha 13 Gene

GNA13 - G protein subunit alpha 13 Gene

中文名称:G 蛋白亚基α13

种属: Homo sapiens

同用名: G13; HG1N

基因 ID: 10672 | 基因类型: protein coding

关于 GNA13

Cytogenetic location: 17q24.1 Genomic coordinates (GRCh38): 17:65,009,289-65,056,740 (from NCBI)

This gene has 2 transcripts (splice variants), 310 orthologues and 15 paralogues. Ubiquitous expression in bone marrow (RPKM 46.2), lymph node (RPKM 22.6) and 24 other tissues.

功能概要

预测启用 D5 多巴胺受体结合活性; G 蛋白β/γ-亚基复合物结合活性;和 GTPase 活性。预计参与多个过程,包括 Rho 蛋白信号转导;激活磷脂酶 D 活性;和多细胞生物老化。预计在几个过程的上游或内部起作用,包括参与血管形态发生的分支;血管相关平滑肌细胞迁移的负调节;血管相关平滑肌细胞增殖的负调节。位于细胞质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable D5 Dopamine Receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in several processes, including Rho protein signal transduction; activation of Phospholipase D activity; and multicellular organism aging. Predicted to act upstream of or within several processes, including branching involved in blood vessel morphogenesis; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GNA13 基因产物(2)

mRNA Protein Name
NM_001282425.2 NP_001269354.1 guanine nucleotide-binding protein subunit alpha-13 isoform 2
NM_006572.6 NP_006563.2 guanine nucleotide-binding protein subunit alpha-13 isoform 1

GNA13 蛋白结构

G-alpha

G-alpha: G-protein alpha subunit (22 - 366)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
蛋白主名 其他名称

guanine nucleotide-binding protein subunit alpha-13

g alpha-13

GNA13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GNA13 Q14344 CXCR5 Homo sapiens P32302
Anti Bait CoIP
23773523
Intra GNA13 Q14344 ARHGEF1 Homo sapiens Q92888
Anti Tag CoIP
12681510
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th

High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

Dendritic Cell Deficiency
Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GNA13 MGD MGI:95768
Canis familiaris GNA13 VGNC VGNC:41298
Macaca mulatta GNA13 VGNC VGNC:73087
Felis catus GNA13 VGNC VGNC:62615
Rattus norvegicus GNA13 RGD RGD:1310221
Bos taurus GNA13 VGNC VGNC:29446