GNB5 - G protein subunit beta 5 Gene

中文名称：G 蛋白亚基β5

种属: Homo sapiens

同用名: GB5; HG2E; IDDCA; LADCI; gbeta5

基因 ID: 10681 | 基因类型: protein coding

关于 GNB5

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,115,100-52,191,392 (from NCBI)

This gene has 12 transcripts (splice variants), 283 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in ovary (RPKM 9.7), kidney (RPKM 8.8) and 25 other tissues.

功能概要

异源三聚体鸟嘌呤核苷酸结合蛋白 (G 蛋白) 整合受体和效应蛋白之间的信号，由 alpha、beta 和 gamma 亚基组成。这些亚基由相关基因家族编码。该基因编码一个β亚基。 β 亚基是 α 亚基以及某些信号转导受体和效应器的重要调节剂。存在编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

GNB5 基因产物(3)

mRNA	Protein	Name
NM_001379343.1	NP_001366272.1	guanine nucleotide-binding protein subunit beta-5 isoform c
NM_006578.4	NP_006569.1	guanine nucleotide-binding protein subunit beta-5 isoform a
NM_016194.4	NP_057278.2	guanine nucleotide-binding protein subunit beta-5 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G-protein gamma-subunit binding	IPI IPI: 通过物理相互作用推断	12606627	GOA
contributes to GTPase activator activity	IDA IDA: 通过直接分析推断	27677260	GOA
enables GTPase activator activity	IDA IDA: 通过直接分析推断	10521509	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12606627	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	19376773	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled dopamine receptor signaling pathway	IDA IDA: 通过直接分析推断	27677260	GOA
involved in negative regulation of voltage-gated calcium channel activity	IDA IDA: 通过直接分析推断	11007869	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	10521509	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	10521509	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNB5 蛋白结构

WD40

0
100
200
300
395 a.a.

蛋白主名

其他名称

guanine nucleotide-binding protein subunit beta-5

G protein, beta subunit 5L

GNB5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GNB5	O14775	PFDN5	Homo sapiens	Q99471	Lumier	25036637
种属内	GNB5	O14775	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	33961781
种属内	GNB5	O14775	RGS6	Homo sapiens	P49758	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder With Cardiac Arrhythmia

Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome	IDDCA
Intellectual Developmental Disorder, With Cardiac Arrhythmia

Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia

LADCI	Language Delay And Adhd/Cognitive Impairment With Or Without Cardiac Arrhythmia
Language Delay, Adhd/Cognitive Impairment With/Without Cardiac Arrhythmia

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Prolonged Electroretinal Response Suppression

Bradyopsia

PERRS

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

Progressive Familial Heart Block, Type Ib

Progressive Familial Heart Block Type Ib	PFHB1B
Pfhbib	Progressive Familial Heart Block Type 1b
Heart Block Progressive Familial Type 1b	Progressive Familial Heart Block 1b
Cardiac Conduction Block	Right-Bundle Branch Block
Heart Block, Familial, Progressive, Type 1b	Heart Block
Right Bundle Branch Block

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05550	GNB5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	GNB5	VGNC	VGNC:80963
Rattus norvegicus	GNB5	RGD	RGD:620759
Mus musculus	GNB5	MGD	MGI:101848
Canis familiaris	GNB5	VGNC	VGNC:41316
Macaca mulatta	GNB5	VGNC	VGNC:73097
Bos taurus	GNB5	VGNC	VGNC:29462

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GNB5 - G protein subunit beta 5 Gene

关于 GNB5

功能概要

GNB5 基因产物(3)

GNB5 蛋白结构

GNB5 蛋白互作信息

关联疾病

直系同源

热门区域

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GNB5 - G protein subunit beta 5 Gene

关于 GNB5

功能概要

GNB5 基因产物(3)

GNB5 蛋白结构

GNB5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z