CNPY3 - canopy FGF signaling regulator 3 Gene

中文名称：canopy FGF 信号调节器 3

种属: Homo sapiens

同用名: CAG4A; DEE60; ERDA5; TNRC5; EIEE60; PRAT4A

基因 ID: 10695 | 基因类型: protein coding

关于 CNPY3

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,928,002-42,939,294 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 21.7), bone marrow (RPKM 19.8) and 25 other tissues.

功能概要

该基因编码的蛋白质结合了 toll 样受体蛋白家族的成员，并作为伴侣蛋白帮助折叠和输出这些蛋白质。可变剪接导致多个转录本变体。自然发生的通读转录发生在该基因座和下游 GNMT (甘氨酸 N-甲基转移酶) 基因之间，用 GeneID：107080644 表示。[RefSeq 提供，2016 年 1 月]

This gene encodes a protein that binds members of the Toll-like Receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]

CNPY3 基因产物(5)

mRNA	Protein	Name
NM_001318842.1	NP_001305771.1	protein canopy homolog 3 isoform 3 precursor
NM_001318845.1	NP_001305774.1	protein canopy homolog 3 isoform 2
NM_001318847.2	NP_001305776.1	protein canopy homolog 3 isoform 5 precursor
NM_001318848.2	NP_001305777.1	protein canopy homolog 3 isoform 6 precursor
NM_006586.5	NP_006577.2	protein canopy homolog 3 isoform 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNPY3 蛋白结构

DUF3456

0
100
200
278 a.a.

蛋白主名

其他名称

protein canopy homolog 3

CAG repeat containing

CNPY3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
种属内	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
种属内	CNPY3	Q9BT09	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
种属内	CNPY3	Q9BT09	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
种属内	CNPY3	Q9BT09	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
种属内	CNPY3	Q9BT09	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
种属内	CNPY3	Q9BT09	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
种属内	CNPY3	Q9BT09	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
种属内	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
种属内	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
种属内	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	CNPY3	Q9BT09	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
种属内	CNPY3	Q9BT09	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
种属内	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CNPY3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75680	CNPY3/PRAT4A Protein, Human (HEK293, Fc)	Q9BT09-1 (G31-P274)	≥95%

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 60

DEE60	Epileptic Encephalopathy, Early Infantile, 60
Eiee60	Developmental And Epileptic Encephalopathy, 60
Early Infantile Epileptic Encephalopathy 60

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Developmental And Epileptic Encephalopathy 27

DEE27	Epileptic Encephalopathy, Early Infantile, 27
Eiee27	Developmental And Epileptic Encephalopathy, 27
Early Infantile Epileptic Encephalopathy 27	Encephalopathy, Developmental And Epileptic, Type 27

Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11	DEE11
Eiee11	Developmental And Epileptic Encephalopathy, 11
Early Infantile Epileptic Encephalopathy 11	Encephalopathy, Developmental And Epileptic, Type 11

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02912	CNPY3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CNPY3	MGD	MGI:1919279
Bos taurus	CNPY3	VGNC	VGNC:27527
Rattus norvegicus	CNPY3	RGD	RGD:1597709
Macaca mulatta	CNPY3	VGNC	VGNC:81055
Felis catus	CNPY3	VGNC	VGNC:61032
Canis familiaris	CNPY3	VGNC	VGNC:39424
Others	CNPY3	NCBI

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