Grm5 - glutamate receptor, metabotropic 5 Gene

中文名称：谷氨酸受体，代谢型 5

种属: Mus musculus

同用名: Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik

关于 Grm5

功能概要

使参与调节突触后膜电位的 G 蛋白偶联受体活性和参与调节突触后细胞溶质钙离子浓度的神经递质受体活性成为可能。参与多个过程，包括使用细胞内钙源的钙介导信号；对淀粉样蛋白-β 的细胞反应；和调节与年龄相关的行为衰退。在学习上游或学习中行动；运动行为；和长期神经元突触可塑性的调节。位于多个细胞成分中，包括 Schaffer 侧支——CA1 突触；神经元投射；和质膜。在中枢神经系统和视网膜中表达。用于研究精神分裂症。与人类 GRM5（谷氨酸代谢受体 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of age-related behavioral decline. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]