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  2. Grm5 - glutamate receptor, metabotropic 5 Gene

Grm5 - glutamate receptor, metabotropic 5 Gene

中文名称:谷氨酸受体,代谢型 5

种属: Mus musculus

同用名: Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik

基因 ID: 108071 | 基因类型: protein coding

关于 Grm5

Chromosome 7: 87,233,376-87,784,115 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 23 phenotypes. Biased expression in CNS E18 (RPKM 1.5), frontal lobe adult (RPKM 8.7) and 4 other tissues.

功能概要

使参与调节突触后膜电位的 G 蛋白偶联受体活性和参与调节突触后细胞溶质钙离子浓度的神经递质受体活性成为可能。参与多个过程,包括使用细胞内钙源的钙介导信号;对淀粉样蛋白-β 的细胞反应;和调节与年龄相关的行为衰退。在学习上游或学习中行动;运动行为;和长期神经元突触可塑性的调节。位于多个细胞成分中,包括 Schaffer 侧支——CA1 突触;神经元投射;和质膜。在中枢神经系统和视网膜中表达。用于研究精神分裂症。与人类 GRM5(谷氨酸代谢受体 5)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of age-related behavioral decline. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 基因产物(2)

mRNA Protein Name
NM_001143834.1 NP_001137306.1 metabotropic glutamate receptor 5 isoform b precursor
NM_001081414.2 NP_001074883.1 metabotropic glutamate receptor 5 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12176012 MGI
enables protein tyrosine kinase activator activity IGI
IGI: 通过遗传相互作用推断
24012003 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
24012003 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
9185557 MGI
involved in learning or memory IGI
IGI: 通过遗传相互作用推断
24012003 MGI
acts upstream of or within locomotory behavior IGI
IGI: 通过遗传相互作用推断
16280580 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
16280580 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
11431513 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
11431513 MGI
involved in positive regulation of calcium-mediated signaling IGI
IGI: 通过遗传相互作用推断
24012003 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
16024054 MGI
involved in synapse organization IGI
IGI: 通过遗传相互作用推断
24012003 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
11431513 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
11431513 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12176012 MGI
is active in dendrite IDA
IDA: 通过直接分析推断
24012003 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
21795692 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12176012 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Grm5 蛋白结构

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (25 - 495)

NCD3G

NCD3G: pfam07562 (506 - 556)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 825)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 601)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (613 - 634)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (643 - 667)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (691 - 711)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (734 - 760)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (768 - 791)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (794 - 819)

DUF5585

DUF5585: cl39316 (1006 - 1184)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1152 - 1202)

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  • 1000
  • 1203 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 5

G protein-coupled receptor GRM5

G protein-coupled receptor, family C, group 1, member E

metabotropic glutamate receptor subtype 5b

metabotropic glutamate receptor type 5

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm5 NCBI NCBI:2915