1. Gene
  2. GRM5 - glutamate metabotropic receptor 5 Gene

GRM5 - glutamate metabotropic receptor 5 Gene

中文名称:谷氨酸代谢受体 5

种属: Homo sapiens

同用名: mGlu5; GPRC1E; MGLUR5; PPP1R86

基因 ID: 2915 | 基因类型: protein coding

关于 GRM5

Cytogenetic location: 11q14.2-q14.3 Genomic coordinates (GRCh38): 11:88,504,642-89,065,982 (from NCBI)

This gene has 5 transcripts (splice variants), 270 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 10.2).

功能概要

该基因编码 G 蛋白偶联受体 3 蛋白家族的成员。编码的蛋白质是变嗜性谷氨酸受体,其信号激活磷脂酰肌醇-钙第二信使系统。这种蛋白质可能参与神经网络活动和突触可塑性的调节。谷氨酸能神经传递涉及正常大脑功能的大多数方面,并且在许多神经病理学状况下可能受到干扰。已在 11 号染色体上定义了该基因的假基因。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 5 月]

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GRM5 基因产物(4)

mRNA Protein Name
NM_001384268.1 NP_001371197.1 metabotropic glutamate receptor 5 isoform b precursor
NM_000842.5 NP_000833.1 metabotropic glutamate receptor 5 isoform b precursor
NM_001143831.3 NP_001137303.1 metabotropic glutamate receptor 5 isoform a precursor
XM_011542792.2 XP_011541094.1 metabotropic glutamate receptor 5 isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
7908515 GOA
enables glutamate receptor activity IDA
IDA: 通过直接分析推断
7908515 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
30675062 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19694902 GOA
enables protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
24012003 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
7908515 GOA
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
24012003 GOA
involved in cognition IMP
IMP: 通过突变表型推断
23227193 GOA
involved in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
24012003 GOA
involved in positive regulation of calcium-mediated signaling IGI
IGI: 通过遗传相互作用推断
24012003 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in dendrite IDA
IDA: 通过直接分析推断
24012003 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
7908515 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GRM5 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (67 - 470)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (508 - 558)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (589 - 825)

GluR_Homer-bdg

GluR_Homer-bdg: Homer-binding domain of metabotropic glutamate receptor (1162 - 1212)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1212 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 5

glutamate receptor, metabotropic 5

protein phosphatase 1, regulatory subunit 86

GRM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GRM5 P41594 NECAB2 Homo sapiens Q7Z6G3-2 19694902
种属内
GRM5 P41594 GRM5 Homo sapiens P41594 30675062
种属内
GRM5 P41594 GRM5 Homo sapiens P41594 30675062
种属内
GRM5 P41594 NECAB2 Homo sapiens Q7Z6G3-1 19694902
种属内
GRM5 P41594 PRKCZ Homo sapiens Q05513
PLA
25241761
种属间: 跨种属相互作用 种属内: 同种属相互作用

GRM5 抗体

目录号 产品名 应用 反应物种
HY-P81764 GRM5 Antibody (YA1509) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

X-Linked Hereditary Ataxia
Central Nervous System Disease

CNS

Cns Diseases

Central Nervous System Diseases

Cns Disorder

Premature Ovarian Failure 1

Ovarian Failure, Premature

Fmr1-Related Primary Ovarian Insufficiency

Fragile X-Associated Primary Ovarian Insufficiency

POF1

Pofx

Hypergonadotropic Ovarian Failure, X-Linked

Pof

Primary Ovarian Insufficiency, Fragile X-Associated

Primary Ovarian Insufficiency 1

Ovarian Failure Premature

Premature Ovarian Failure, X-Linked

Fragile X Premature Ovarian Failure

Fmr1-Related Premature Ovarian Failure

Familial Premature Ovarian Failure

Idiopathic Familial Premature Ovarian Failure

Fxpoi

X-Linked Hypergonadotropic Ovarian Failure

Hypergonadotropic Ovarian Failure X-Linked

Poi

Premature Ovarian Failure X-Linked

Primary Ovarian Insufficiency

Premature Ovarian Failure-1

Ovarian Failure, Premature, Type 1

Premature Ovarian Failure, Familial

Premature Menopause

Primary Hypogonadism

Turner Syndrome

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Gallbladder Small Cell Carcinoma

Oat Cell Carcinoma Of The Gallbladder

Gallbladder Small Cell Neuroendocrine Carcinoma

Anterograde Amnesia

Amnesia, Anterograde

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders

Ganglioglioma

Childhood Ganglioglioma

Adult Ganglioglioma

Cns Ganglioglioma

Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Specific Developmental Disorder
Substance Dependence
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

X-Linked Monogenic Disease
Status Epilepticus

Grand Mal Status Epilepticus

Grand Mal Status

Gcse

Generalized Convulsive Status Epilepticus

Se

Epilepsy With Status Epilepticus

Focal Epilepsy

Partial Epilepsy

Epilepsies, Partial

Localisation-Related Epilepsy

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Schizophrenia 6

SCZD6

Schizophrenia Susceptibility Locus, Chromosome 8p-Related

Schizophrenia, Type 6

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Granulomatous Angiitis

Vasculitis, Central Nervous System

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus GRM5 VGNC VGNC:103033
Rattus norvegicus GRM5 RGD RGD:2746
Bos taurus GRM5 VGNC VGNC:56292
Mus musculus GRM5 MGD MGI:1351342
Macaca mulatta GRM5 VGNC VGNC:73289
Canis familiaris GRM5 VGNC VGNC:41512
Others GRM5 NCBI