2. Gene
  3. Grm7 - glutamate receptor, metabotropic 7 Gene

Grm7 - glutamate receptor, metabotropic 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸受体，代谢型 7

种属: Mus musculus

同用名: SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb

基因 ID: 108073 | 基因类型: protein coding

关于 Grm7

Chromosome 6: 110,622,542-111,544,191 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 22 phenotypes. Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues.

功能概要

该基因编码的蛋白可启动钙通道调节剂活动和电压门控钙通道活动。参与化学突触传递和突触小泡胞吐的调节。在多个流程的上游或内部采取行动，包括行为恐惧反应；学习或记忆；和神经冲动的传递。位于谷氨酸能突触和突触前膜。以多种结构表达，包括消化系统；脑;眼睛;生殖系统;和脊髓。与人类 GRM7（谷氨酸代谢受体 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calcium Channel regulator activity and voltage-gated Calcium Channel activity. Involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 基因产物(2)

mRNA Protein Name
NM_001346640.1 NP_001333569.1 metabotropic glutamate receptor 7 isoform 2 precursor
NM_177328.3 NP_796302.2 metabotropic glutamate receptor 7 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel regulator activity IDA
IDA: 通过直接分析推断
11584003 MGI
enables voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
12065412 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult behavior IMP
IMP: 通过突变表型推断
12814372 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
16775145 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
9920659 MGI
involved in chemical synaptic transmission IDA
IDA: 通过直接分析推断
12065412 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: 通过突变表型推断
9920659 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
16204199 MGI
acts upstream of or within multicellular organismal response to stress IMP
IMP: 通过突变表型推断
12814372 MGI
acts upstream of or within nervous system process IMP
IMP: 通过突变表型推断
16204199 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
12065412 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
12065412 MGI
acts upstream of or within short-term memory IMP
IMP: 通过突变表型推断
15313036 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: 通过突变表型推断
11698585 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
12065412 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
12065412 MGI
located in presynaptic membrane IDA
IDA: 通过直接分析推断
12065412 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm7 蛋白结构

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 510)

NCD3G

NCD3G: pfam07562 (518 - 568)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 613)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 894)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (625 - 646)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (655 - 679)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (701 - 721)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (751 - 777)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (785 - 808)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (818 - 843)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 7

G protein-coupled receptor GRM7

G protein-coupled receptor, family C, group 1, member G

mGlu7a receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05837 GRM7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05838 Grm7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05839 Grm7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm7 NCBI NCBI:2917
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z