GRM7 - glutamate metabotropic receptor 7 Gene

中文名称：谷氨酸代谢受体 7

种属: Homo sapiens

同用名: GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87

基因 ID: 2917 | 基因类型: protein coding

关于 GRM7

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:6,861,115-7,741,533 (from NCBI)

This gene has 15 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

功能概要

L-谷氨酸是中枢神经系统中主要的兴奋性神经递质，它激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常大脑功能的大多数方面，并且在许多神经病理学状况下可能受到干扰。代谢型谷氨酸受体是一个 G 蛋白偶联受体家族，根据序列同源性、推定的信号转导机制和药理学特性将其分为三组。 I 组包括 GRM1 和 GRM5，这些受体已显示可激活磷脂酶 C。II 组包括 GRM2 和 GRM3，而 III 组包括 GRM4、GRM6、GRM7 和 GRM8。 II 组和 III 组受体与环 AMP 级联的抑制有关，但它们的激动剂选择性不同。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 6 月]

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GRM7 基因产物(8)

mRNA	Protein	Name
NM_000844.4	NP_000835.1	metabotropic glutamate receptor 7 isoform a precursor
XM_017006273.2	XP_016861762.1	metabotropic glutamate receptor 7 isoform X4
XM_047448053.1	XP_047304009.1	metabotropic glutamate receptor 7 isoform X2
XM_017006272.2	XP_016861761.1	metabotropic glutamate receptor 7 isoform X3
XR_001740135.3
XM_047448052.1	XP_047304008.1	metabotropic glutamate receptor 7 isoform X1
NM_181875.1
NM_181874.3	NP_870989.1	metabotropic glutamate receptor 7 isoform b precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables adenylate cyclase inhibitor activity	IDA IDA: 通过直接分析推断	9144652	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	18599484	GOA
enables glutamate binding	IDA IDA: 通过直接分析推断	9144652	GOA
enables glutamate receptor activity	IDA IDA: 通过直接分析推断	9473604	GOA
enables group III metabotropic glutamate receptor activity	IDA IDA: 通过直接分析推断	9144652	GOA
enables protein dimerization activity	IMP IMP: 通过突变表型推断	33476302	GOA
enables serine binding	IDA IDA: 通过直接分析推断	9144652	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA IDA: 通过直接分析推断	9473604	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	9144652	GOA
involved in axon development	IMP IMP: 通过突变表型推断	33500274	GOA
NOT involved in behavioral fear response	IMP IMP: 通过突变表型推断	17167337	GOA
involved in chemical synaptic transmission	IDA IDA: 通过直接分析推断	9473604	GOA
involved in glycosylation	IDA IDA: 通过直接分析推断	33500274	GOA
involved in sensory perception of sound	IMP IMP: 通过突变表型推断	19047183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell cortex	IDA IDA: 通过直接分析推断	9630572	GOA
located in dendrite	IDA IDA: 通过直接分析推断	9630572	GOA
located in membrane	IDA IDA: 通过直接分析推断	12746871	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	33500274	GOA
part of receptor complex	IDA IDA: 通过直接分析推断	23382219	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRM7 蛋白结构

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
915 a.a.

蛋白主名

其他名称

metabotropic glutamate receptor 7

glutamate receptor, metabotropic 7

protein phosphatase 1, regulatory subunit 87

关联疾病

疾病名称

别名

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type

Mecp2 Duplication Syndrome	Lubs X-Linked Mental Retardation Syndrome
MRXSL	Trisomy Xq28
Mental Retardation, X-Linked, With Recurrent Respiratory Infections	Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type
Mental Retardation, X-Linked, Lubs Type	Xlmr Syndrome, Lubs Type

Gene Duplication Disease

Gene Duplication Syndrome

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities

NEDSHBA

Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Abnormalities

Deafness, Autosomal Dominant 28

DFNA28	Autosomal Dominant Nonsyndromic Deafness 28
Autosomal Dominant Deafness 28	Deafness, Autosomal Dominant, 28
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28
Deafness, Autosomal Dominant, Type 28

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Suppression Bursts	Early Infantile Epileptic Encephalopathy With Burst-Suppression
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Amyotrophic Lateral Sclerosis 19

Amyotrophic Lateral Sclerosis Type 19	ALS19
Sclerosis, Lateral, Amyotrophic, Type 19

Hypotonia

Cerebral Atrophy

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Deafness, Autosomal Dominant 64

DFNA64	Autosomal Dominant Nonsyndromic Deafness 64
Autosomal Dominant Deafness 64	Deafness, Autosomal Dominant, 64
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64
Deafness, Autosomal Dominant, Type 64

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GRM7	MGD	MGI:1351344
Bos taurus	GRM7	VGNC	VGNC:29662
Macaca mulatta	GRM7	VGNC	VGNC:73291
Canis familiaris	GRM7	VGNC	VGNC:41514
Rattus norvegicus	GRM7	RGD	RGD:619857
Felis catus	GRM7	VGNC	VGNC:102595

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