2. Gene
  3. ADAM28 - ADAM metallopeptidase domain 28 Gene

ADAM28 - ADAM metallopeptidase domain 28 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 28

种属: Homo sapiens

同用名: MDCL; MDC-L; eMDCII; ADAM 28; eMDC II

基因 ID: 10863 | 基因类型: protein coding

关于 ADAM28

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:24,294,069-24,359,014 (from NCBI)

This gene has 13 transcripts (splice variants), 247 orthologues and 20 paralogues. Biased expression in stomach (RPKM 21.4), gall bladder (RPKM 11.1) and 12 other tissues.

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。该基因编码的蛋白质是淋巴细胞表达的 ADAM 蛋白。该基因与 ADAM 家族的其他成员一起存在于 8 号染色体上的基因簇中。可变剪接导致多个转录变体。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with Other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ADAM28 基因产物(3)

mRNA Protein Name
NM_001304351.2 NP_001291280.1 disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein
NM_014265.6 NP_055080.2 disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein
NM_021777.5 NP_068547.2 disintegrin and metalloproteinase domain-containing protein 28 isoform 3 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables immunoglobulin receptor binding IPI
IPI: 通过物理相互作用推断
12777399 GOA
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
12777399 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM28 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (28 - 155)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (204 - 399)

Disintegrin

Disintegrin: Disintegrin (416 - 490)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (493 - 576)

  • 0
  • 200
  • 400
  • 600
  • 775 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 28

epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

ADAM28 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADAM28 Q9UKQ2 PLAU Homo sapiens P00749
Y2H Array
32296183
种属内
ADAM28 Q9UKQ2 PLAU Homo sapiens P00749
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyperostosis Cranialis Interna

HCIN

Hyperostosis Cranalis Interna
Epilepsy, Familial Temporal Lobe, 1

ETL1

Adpeaf

Adlte

Epilepsy, Partial, With Auditory Features

Autosomal Dominant Partial Epilepsy With Auditory Features

Epilepsy, Lateral Temporal Lobe, Autosomal Dominant

Familial Temporal Lobe Epilepsy 1

Partial Epilepsy With Auditory Features

Autosomal Dominant Lateral Temporal Lobe Epilepsy

Lateral Temporal Lobe Epilepsy Autosomal Dominant

Epilepsy, Temporal Lobe, Familial, Type 1
Hyperostosis

Hypertrophy Of Bone

Bone Hypertrophy

Bone Thickening

Periosteum Thickening
Asbestos-Related Lung Carcinoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00280 ADAM28 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADAM28 VGNC VGNC:69486
Canis familiaris ADAM28 VGNC VGNC:37582
Felis catus ADAM28 VGNC VGNC:59582
Rattus norvegicus ADAM28 RGD RGD:727820
Mus musculus ADAM28 MGD MGI:105988
Others ADAM28 NCBI
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