1. Gene
  2. TRAFD1 - TRAF-type zinc finger domain containing 1 Gene

TRAFD1 - TRAF-type zinc finger domain containing 1 Gene

中文名称:含 TRAF 型锌指结构域 1

种属: Homo sapiens

同用名: FLN29

基因 ID: 10906 | 基因类型: protein coding

关于 TRAFD1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,125,560-112,153,604 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 16.4) and 25 other tissues.

功能概要

先天免疫系统赋予宿主防御病毒和微生物感染的能力,而 TRAFD1 是控制过度免疫反应的负反馈调节剂 (Sanada 等人,2008 [PubMed 18849341]) 。[OMIM 提供,2009 年 12 月]

The innate immune system confers host defense against viral and microbial Infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

TRAFD1 基因产物(2)

mRNA Protein Name
NM_001143906.2 NP_001137378.1 TRAF-type zinc finger domain-containing protein 1
NM_006700.3 NP_006691.1 TRAF-type zinc finger domain-containing protein 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

TRAF-type zinc finger domain-containing protein 1

FLN29 gene product

TRAFD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAFD1 O14545 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra TRAFD1 O14545 HTT Homo sapiens P42858
Y2H
17500595
Intra TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Y2H Array
31515488
Intra TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Validated Y2H
25416956
Intra TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus

Central Nervous System Tuberculosis

Intracranial Tuberculoma

Tuberculoma Of Brain

Tuberculosis Of Meninges And Central Nervous System

Tuberculous Abscess Of Brain

Tuberculoma, Intracranial

Tuberculosis, Central Nervous System

Type 1 Diabetes Mellitus 3

Diabetes Mellitus, Insulin-Dependent, 3

Iddm3

Insulin-Dependent Diabetes Mellitus 3

T1D3

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRAFD1 RGD RGD:620171
Felis catus TRAFD1 VGNC VGNC:66503
Bos taurus TRAFD1 VGNC VGNC:97319
Macaca mulatta TRAFD1 VGNC VGNC:79459
Canis familiaris TRAFD1 VGNC VGNC:47771
Mus musculus TRAFD1 MGD MGI:1923551