SEC61B - SEC61 translocon subunit beta Gene

中文名称：SEC61 易位子亚基β

种属: Homo sapiens

基因 ID: 10952 | 基因类型: protein coding

关于 SEC61B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:99,222,282-99,230,615 (from NCBI)

This gene has 3 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in adrenal (RPKM 68.2), appendix (RPKM 66.5) and 25 other tissues.

功能概要

Sec61 复合体是内质网 (ER) 膜蛋白质易位装置的核心组成部分。 Sec61 复合物的寡聚体形成一个跨膜通道，蛋白质在此跨膜通道转运并整合到 ER 膜中。该复合物由三种膜蛋白组成——α、β 和γ。该基因编码 β-亚基蛋白。在后 ER 区室中也观察到 Sec61 亚基，表明这些蛋白质可以逃脱 ER 并循环回去。有证据表明该转录本有多个聚腺苷酸化位点。[RefSeq 提供，2008 年 7 月]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

SEC61B 基因产物(1)

mRNA	Protein	Name
NM_006808.3	NP_006799.1	protein transport protein Sec61 subunit beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables epidermal growth factor binding	IPI IPI: 通过物理相互作用推断	19602593	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9792704	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	32820719	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IDA IDA: 通过直接分析推断	8945469	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: 通过突变表型推断	17215517	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	18555783	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	27044890	GOA
located in endoplasmic reticulum quality control compartment	IDA IDA: 通过直接分析推断	17707796	GOA
located in membrane	IDA IDA: 通过直接分析推断	22375059	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC61B 蛋白结构

Sec61_beta

0
96 a.a.

蛋白主名

其他名称

protein transport protein Sec61 subunit beta

SEC61 translocon beta subunit

SEC61B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SEC61B	P60468	SEC61A2	Homo sapiens	Q9H9S3	Anti Tag CoIP	35271311
Cross	SEC61B	P60468	ns7b_sars2	SARS-CoV-2	P0DTD8	Anti Tag CoIP	36217030
Cross	SEC61B	P60468	GET3	Saccharomyces cerevisiae	Q12154	Crosslink	21866104
Cross	SEC61B	P60468	GET3	Saccharomyces cerevisiae	Q12154	Pull Down	21866104
Intra	SEC61B	P60468	SSR1	Homo sapiens	P43307	Anti Bait CoIP	17380188
Intra	SEC61B	P60468	SSR1	Homo sapiens	P43307	Anti Tag CoIP	35271311
Intra	SEC61B	P60468	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	18555783
Intra	SEC61B	P60468	BCAP31	Homo sapiens	P51572	Anti Tag CoIP	18555783
Intra	SEC61B	P60468	BCAP31	Homo sapiens	P51572	Ub Reconstruction	18555783

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12622	SEC61B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SEC61B	MGD	MGI:1913462
Bos taurus	SEC61B	VGNC	VGNC:49570
Rattus norvegicus	SEC61B	RGD	RGD:1304997
Felis catus	SEC61B	VGNC	VGNC:64974
Canis familiaris	SEC61B	VGNC	VGNC:49616

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SEC61B - SEC61 translocon subunit beta Gene

关于 SEC61B

功能概要

SEC61B 基因产物(1)

SEC61B 蛋白结构

SEC61B 蛋白互作信息

关联疾病

直系同源

热门区域

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SEC61B - SEC61 translocon subunit beta Gene

关于 SEC61B

功能概要

SEC61B 基因产物(1)

SEC61B 蛋白结构

SEC61B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z