PDIA5 - protein disulfide isomerase family A member 5 Gene

中文名称：蛋白质二硫键异构酶家族 A 成员 5

种属: Homo sapiens

同用名: PDIR

关于 PDIA5

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、三个催化活性硫氧还蛋白 (TRX) 结构域、一个 TRX 样结构域和一个 C 端 ER 保留序列。 N 末端 TRX 样结构域是主要 ER 伴侣钙网蛋白以及可能的其他蛋白质和底物的主要结合位点。可变剪接导致多种蛋白质编码和非蛋白质编码的转录物变体。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly Other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]