2. Gene
  3. MLLT11 - MLLT11 transcription factor 7 cofactor Gene

MLLT11 - MLLT11 transcription factor 7 cofactor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MLLT11 转录因子 7 辅助因子

种属: Homo sapiens

同用名: AF1Q

基因 ID: 10962 | 基因类型: protein coding

关于 MLLT11

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,060,397-151,069,544 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and is associated with 37 phenotypes. Biased expression in brain (RPKM 95.2), heart (RPKM 17.4) and 3 other tissues.

功能概要

位于 11q23 的基因以 ALL1、HRX 或 MLL 的不同符号表示，已被证明在白血病病例中与许多易位伙伴融合。 t (1;11) (q21;q23) 易位将 MLL 基因与 2 名患有急性粒单核细胞白血病的婴儿的染色体带 1q21 上的基因融合。 MLL 基因的 N 末端部分对于涉及带 11q23 的易位中的白血病发生至关重要。该基因编码 90 个氨基酸。发现它在胸腺中高表达，但在外周淋巴组织中不高表达。与其在正常造血组织中的限制性分布相反，该基因在所有测试的白血病细胞系中均有表达。[RefSeq 提供，2008 年 7 月]

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 Amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

MLLT11 基因产物(1)

mRNA Protein Name
NM_006818.4 NP_006809.1 protein AF1q
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26079538 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
18852119 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
18852119 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18852119 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
18852119 GOA
involved in positive regulation of mitochondrial depolarization IDA
IDA: 通过直接分析推断
18852119 GOA
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
18852119 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MLLT11 蛋白结构

WRNPLPNID

WRNPLPNID: Putative WW-binding domain and destruction box (3 - 61)

  • 0
  • 90 a.a.
蛋白主名 其他名称

protein AF1q

ALL1 fused gene from chromosome 1q

MLLT11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MLLT11 Q13015 TCF7 Homo sapiens P36402
Anti Bait CoIP
26079538
种属内
MLLT11 Q13015 TCF7 Homo sapiens P36402
Y2H
26079538
种属内
MLLT11 Q13015 S100B Homo sapiens P04271
Anti Tag CoIP
33961781
种属内
MLLT11 Q13015 S100B Homo sapiens P04271
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Myelomonocytic Leukemia

Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

16)(P13

Q22)

Aml M4

Ammol

Acute Myeloblastic Leukemia Type 4

Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

16)(P13

Q22)

Aml-M4

Aml With Inv(16)(P13.1q22) Or T(16

16)(P13.1

Q22)

Cbfb-Myh11

Leukemia Myelomonocytic Acute

Leukemia, Myelomonocytic, Acute

Acute Myelomonocytic Leukaemia Without Mention Of Remission

Myelomonocytic Leukaemia Nos
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia

Paediatric Acute Myeloid Leukaemia

Pediatric Acute Myeloid Leukemia
Intellectual Developmental Disorder, X-Linked 109

Fraxe Syndrome

Fragile Xe Syndrome

Mental Retardation, X-Linked, Fraxe Type

XLID109

Mrx109

Mental Retardation, X-Linked, Associated With Fragile Site Fraxe

Fraxe Mental Retardation Syndrome

X-Linked Intellectual Developmental Disorder 109

Fraxe Intellectual Disability

Fraxe

Mental Retardation, X-Linked 109

Fragile Site On Chromosome Xq28

Fragile Site, Folic Acid Type

X-Linked Intellectual Disability Associated With Fragile Site Fraxe

Fraxe Intellectual Deficit

Intellectual Disability Associated With Fragile Site Fraxe
Childhood Leukemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08495 MLLT11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MLLT11 VGNC VGNC:100011
Canis familiaris MLLT11 VGNC VGNC:43261
Felis catus MLLT11 VGNC VGNC:63525
Rattus norvegicus MLLT11 RGD RGD:1305525
Bos taurus MLLT11 VGNC VGNC:31502
Mus musculus MLLT11 MGD MGI:1929671
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