Glo1 - glyoxalase 1 Gene

中文名称：乙二醛酶1

种属: Mus musculus

同用名: GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik

关于 Glo1

功能概要

该基因编码的蛋白可启动乳酰谷胱甘肽裂解酶活性和锌离子结合活性。参与破骨细胞分化。在 RNA 聚合酶 II 的转录调节上游或调节内起作用。预测位于胞质溶胶中；核质；和质膜。在中枢神经系统和视网膜中表达。该基因的人类直系同源物与自闭症有关；糖尿病性视网膜病变;晚期肾脏疾病; 2型糖尿病；和血管疾病。与人 GLO1（乙二醛酶 I）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]