2. Gene
  3. F11 - coagulation factor XI Gene

F11 - coagulation factor XI Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: FXI; PTA; Cf11; 1600027G01Rik

基因 ID: 109821 | 基因类型: protein coding

关于 F11

功能概要

This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, Thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and Bacterial accumulation upon Infection with Listeria. [provided by RefSeq, Apr 2015]

F11 基因产物(2)

mRNA Protein Name
NM_001411665.1 NP_001398594.1 coagulation factor XI isoform 2
NM_028066.3 NP_082342.1 coagulation factor XI isoform 1 preproprotein
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within regulation of blood coagulation IMP
IMP: 通过突变表型推断
16533887 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

coagulation factor XI

plasma thromboplastin antecedent

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162065 N6F11 Inducer 98.37% 否
HY-N0541 Pseudoginsenoside F11 99.87% 否
HY-N6650 Isotanshinone IIA ≥98.0% 否
HY-19606 Cytogenin Inhibitor / 否
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04625 F11 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W472509 11-HETE Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens F11 NCBI NCBI:2160
Canis familiaris F11 NCBI NCBI:475623
Macaca fascicularis F11 NCBI NCBI:102143421
Leporidae F11 NCBI
Rattus norvegicus F11 NCBI NCBI:290757
Macaca mulatta F11 NCBI NCBI:702117
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