METAP2 - methionyl aminopeptidase 2 Gene

中文名称：甲硫氨酰氨肽酶 2

种属: Homo sapiens

同用名: MAP2; MNPEP; p67eIF2

关于 METAP2

功能概要

由该基因编码的蛋白质是甲硫氨酰氨基肽酶家族的成员。编码的蛋白质通过保护真核起始因子 2 的 α 亚基免受抑制性磷酸化以及通过从新生蛋白质中去除氨基末端甲硫氨酸残基来发挥作用。这种基因表达的增加与各种形式的癌症有关，抗癌药物夫马洁林和 ovalicin 通过不可逆地与其活性位点结合来抑制这种蛋白质。该基因的抑制剂也已被证明可有效治疗肥胖症。该基因的假基因位于 2 号染色体上。已发现该基因的几种编码不同亚型的转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a member of the methionyl Aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of Cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]