LILRB4 - leukocyte immunoglobulin like receptor B4 Gene

中文名称：白细胞免疫球蛋白样受体 B4

种属: Homo sapiens

同用名: B4; ILT3; LIR5; CD85K; ILT-3; LIR-5

关于 LILRB4

功能概要

该基因是白细胞免疫球蛋白样受体 (LIR) 家族的成员，该家族位于染色体区域 19q13.4 的基因簇中。编码的蛋白质属于 B 类 LIR 受体亚科，其中包含两个或四个细胞外免疫球蛋白结构域、一个跨膜结构域和两个至四个基于细胞质免疫受体酪氨酸的抑制基序 (ITIM) 。该受体在免疫细胞上表达，在那里它与抗原呈递细胞上的 MHC I 类分子结合，并转导抑制免疫反应刺激的负信号。该受体还可以在抗原捕获和呈递中发挥作用。它被认为可以控制炎症反应和细胞毒性，以帮助集中免疫反应并限制自身反应性。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]