1. Gene
  2. TRIM31 - tripartite motif containing 31 Gene

TRIM31 - tripartite motif containing 31 Gene

中文名称:含三方基序 31

种属: Homo sapiens

同用名: RNF; HCG1; HCGI; C6orf13

基因 ID: 11074 | 基因类型: protein coding

关于 TRIM31

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,102,897-30,113,090 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 46 orthologues and 80 paralogues. Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues.

功能概要

该基因编码的蛋白质起着 E3 泛素-蛋白质连接酶的作用。该基因在某些肿瘤中表现出改变的表达,可能是细胞生长的负调节因子。可变剪接导致多个转录本变体。[RefSeq 提供,2016 年 1 月]

This gene encodes a protein that functions as an E3 ubiquitin-protein Ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TRIM31 基因产物(1)

mRNA Protein Name
NM_007028.5 NP_008959.3 E3 ubiquitin-protein ligase TRIM31
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23077300 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
27929086 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
27992402 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
27992402 GOA
involved in innate immune response IMP
IMP: 通过突变表型推断
18248090 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
27929086 GOA
involved in negative regulation of viral entry into host cell IMP
IMP: 通过突变表型推断
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: 通过直接分析推断
18248090 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
23077300 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
27929086 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
27992402 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27929086 GOA
involved in viral release from host cell IMP
IMP: 通过突变表型推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
27992402 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM31 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 56)

zf-B_box

zf-B_box: B-box zinc finger (91 - 130)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM31

RING-type E3 ubiquitin transferase TRIM31

TRIM31 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM31 Q9BZY9 UBE2K Homo sapiens P61086 32814053
种属内
TRIM31 Q9BZY9 UBE2K Homo sapiens P61086 32814053
种属内
TRIM31 Q9BZY9 UBE2K Homo sapiens P61086 32814053
种属内
TRIM31 Q9BZY9 MAGEA1 Homo sapiens P43355 25416956
种属内
TRIM31 Q9BZY9 MAGEA1 Homo sapiens P43355 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRIM31 VGNC VGNC:36327
Rattus norvegicus TRIM31 RGD RGD:1308607
Mus musculus TRIM31 MGD MGI:2385051