AKR1C4 - aldo-keto reductase family 1 member C4 Gene

中文名称：醛酮还原酶家族 1 成员 C4

种属: Homo sapiens

同用名: C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD

基因 ID: 1109 | 基因类型: protein coding

关于 AKR1C4

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,196,837-5,218,949 (from NCBI)

This gene has 3 transcripts (splice variants), 484 orthologues, 16 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 165.8).

功能概要

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。这些酶利用 NADH 和/或 NADPH 作为辅助因子，催化醛和酮转化为其相应的醇。这些酶显示重叠但不同的底物特异性。这种酶催化十氯酮 (一种有毒的有机氯农药) 在肝脏中生物还原为十氯酮醇。该基因与其他三个基因成员具有高度序列同一性，并与染色体 10p15-p14 上的这三个基因聚集在一起。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This Enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

AKR1C4 基因产物(1)

mRNA	Protein	Name
NM_001818.5	NP_001809.4	aldo-keto reductase family 1 member C4

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables androsterone dehydrogenase activity	IDA IDA: 通过直接分析推断	21851338	GOA
enables chlordecone reductase activity	IDA IDA: 通过直接分析推断	2427522	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: 通过直接分析推断	20837989	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables retinal dehydrogenase activity	IDA IDA: 通过直接分析推断	21851338	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to jasmonic acid stimulus	IDA IDA: 通过直接分析推断	19487289	GOA
involved in daunorubicin metabolic process	IMP IMP: 通过突变表型推断	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: 通过突变表型推断	20837989	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKR1C4 蛋白结构

Aldo_ket_red

0
100
200
300
323 a.a.

蛋白主名

其他名称

aldo-keto reductase family 1 member C4

3-alpha-HSD1

重组 AKR1C4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7470	AKR1C4 Protein, Human (His)	P17516 (M1-Y323)	≥95%

关联疾病

疾病名称

别名

46,Xy Sex Reversal 8

SRXY8	Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase
Tdd	46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency
46xy Sex Reversal 8	46xy Sex Reversal 8, Modifier Of
Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Cloacal Exstrophy

Oeis Complex	Omphalocele-Cloacal Exstrophy-Imperforate Anus-Spinal Defect Syndrome
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Compl	Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Complex
Cloacal Exstrophy Sequence	Omphalocele - Cloacal Exstrophy - Imperforate Anus - Spinal Defect
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects	Omphalocele Exstrophy Imperforate Anus

Bile Acid Synthesis Defect, Congenital, 3

Congenital Bile Acid Synthesis Defect 3	CBAS3
Oxysterol 7-Alpha-Hydroxylase Deficiency	Congenital Bile Acid Synthesis Defect Type 3
Basd3	Bile Acid Synthesis Defect, Congenital, Type 3

Cytochrome P450 Oxidoreductase Deficiency

Por Deficiency	Pord
Antley-Bixler Syndrome With Disordered Steroidogenesis	Antley-Bixler Syndrome
Antley-Bixler Syndrome-Like Phenotype With Disordered Steroidogenesis	Combined Partial Deficiency Of 17-Hydroxylase And 21-Hydroxylase
Congenital Adrenal Hyperplasia Due To Apparent Combined P450c17 And P450c21 Deficiency	Antley-Bixler Syndrome, Autosomal Dominant

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-150644	S07-2010	Inhibitor	99.79%	否
HY-P2901	3α-Hydroxysteroid Dehydrogenase, Microorganism		90.00%	否
HY-150649	S07-2005 (racemic)		/	否
HY-RS00537	AKR1C4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Others	AKR1C4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AKR1C4 - aldo-keto reductase family 1 member C4 Gene

关于 AKR1C4

功能概要

AKR1C4 基因产物(1)

AKR1C4 蛋白结构

重组 AKR1C4 蛋白

关联疾病

直系同源

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AKR1C4 - aldo-keto reductase family 1 member C4 Gene

关于 AKR1C4

功能概要

AKR1C4 基因产物(1)

AKR1C4 蛋白结构

重组 AKR1C4 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

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T

X

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