FICD - FIC domain protein adenylyltransferase Gene

中文名称：FIC 结构域蛋白腺苷酸转移酶

种属: Homo sapiens

同用名: HYPE; HIP13; UNQ3041

基因 ID: 11153 | 基因类型: protein coding

关于 FICD

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), testis (RPKM 4.5) and 25 other tissues.

功能概要

启用多项功能，包括 ATP 绑定活动； HSP70 蛋白结合活性；和伴侣结合活性。参与蛋白质腺苷酸化；调节 IRE1 介导的未折叠蛋白反应；和对内质网应激的反应。是内质网膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; HSP70 protein binding activity; and chaperone binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

FICD 基因产物(1)

mRNA	Protein	Name
NM_007076.3	NP_009007.2	protein adenylyltransferase FICD

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables AMPylase activity	IDA IDA: 通过直接分析推断	19362538	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	25435325	GOA
enables Hsp70 protein binding	IPI IPI: 通过物理相互作用推断	25601083	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	22266942	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	25435325	GOA
enables protein-folding chaperone binding	IDA IDA: 通过直接分析推断	25601083	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein adenylylation	IDA IDA: 通过直接分析推断	22266942	GOA
involved in regulation of IRE1-mediated unfolded protein response	IDA IDA: 通过直接分析推断	25601083	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	25601083	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	25601083	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FICD 蛋白结构

Fic

0
100
200
300
400
458 a.a.

蛋白主名

其他名称

protein adenylyltransferase FICD

AMPylator FICD

FICD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FICD	Q9BVA6	FICD	Homo sapiens	Q9BVA6	X-Ray Diffraction	25435325
种属内	FICD	Q9BVA6	ADK	Homo sapiens	P55263	Y2H Array	21988832
种属内	FICD	Q9BVA6	RAC1	Homo sapiens	P63000-1	Ampylation	22266942
种属内	FICD	Q9BVA6	FICD	Homo sapiens	Q9BVA6	GMS	25435325
种属内	FICD	Q9BVA6	CDC42	Homo sapiens	P60953-2	Ampylation	22266942
种属内	FICD	Q9BVA6	FICD	Homo sapiens	Q9BVA6	SAXS	25435325

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cone-Rod Dystrophy 13

CORD13

Dystrophy, Cone-Rod, Type 13

Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses

Progressive Familial Heart Block

Hereditary Bundle Branch Defect	Hereditary Bundle Branch System Defect
Familial Lenegre Disease	Familial Lev Disease
Familial Lev-Lenegre Disease	Familial Pccd
Familial Progressive Heart Block	Pfhb
Bundle Branch Block	Hbbd
Lenegre Lev Disease	Lev Syndrome
Lev'S Disease	Lev-Lenègre Disease
Pccd	Progressive Cardiac Conduction Defect
Bundle-Branch Block

Schizotypal Personality Disorder

Schizotypal Personality

Cholestasis, Progressive Familial Intrahepatic, 1

PFIC1	Byler Disease
Cholestasis, Progressive Familial Intrahepatic 1	Progressive Familial Intrahepatic Cholestasis 1
Progressive Familial Intrahepatic Cholestasis Type 1	Fic1 Deficiency
Byler'S Disease	Cholestasis, Fatal Intrahepatic
Progressive Familial Intrahepatic Cholestasis	Severe Atp8b1 Deficiency
Fatal Intrahepatic Cholestasis	Cholestasis, Intrahepatic, Familial, Progressive, Type 1
Progressive Intrahepatic Cholestasis	Cholestasis, Progressive Familial Intrahepatic 3

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04943	FICD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FICD	VGNC	VGNC:107705
Rattus norvegicus	FICD	RGD	RGD:1359391
Bos taurus	FICD	VGNC	VGNC:29007
Mus musculus	FICD	MGD	MGI:1098550
Macaca mulatta	FICD	VGNC	VGNC:82081
Canis familiaris	FICD	VGNC	VGNC:52933

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FICD - FIC domain protein adenylyltransferase Gene

关于 FICD

功能概要

FICD 基因产物(1)

FICD 蛋白结构

FICD 蛋白互作信息

关联疾病

直系同源

热门区域

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FICD - FIC domain protein adenylyltransferase Gene

关于 FICD

功能概要

FICD 基因产物(1)

FICD 蛋白结构

FICD 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z