FAM107A - family with sequence similarity 107 member A Gene

中文名称：具有序列相似性的家族 107 成员 A

种属: Homo sapiens

同用名: DRR1; TU3A

基因 ID: 11170 | 基因类型: protein coding

关于 FAM107A

Cytogenetic location: 3p14.3-p14.2 Genomic coordinates (GRCh38): 3:58,564,117-58,627,610 (from NCBI)

This gene has 8 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in brain (RPKM 151.8), lung (RPKM 18.6) and 7 other tissues.

功能概要

预测启用肌动蛋白结合活性。参与多个过程，包括有丝分裂细胞周期 G1/S 转换的负调控；粘着斑组装的负调控；和细胞骨架组织的调节。位于多个细胞成分中，包括粘着斑；荷叶边膜；和应力纤维。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of Cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

FAM107A 基因产物(4)

mRNA	Protein	Name
NM_001076778.3	NP_001070246.1	actin-associated protein FAM107A isoform a
NM_001282713.2	NP_001269642.1	actin-associated protein FAM107A isoform b
NM_001282714.2	NP_001269643.1	actin-associated protein FAM107A isoform c
NM_007177.4	NP_009108.1	actin-associated protein FAM107A isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20543869	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	28604741	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: 通过突变表型推断	20543869	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	20543869	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	28604741	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	20543869	GOA
involved in regulation of cell growth	IDA IDA: 通过直接分析推断	10564580	GOA
involved in regulation of microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	20543869	GOA
involved in regulation of protein stability	IMP IMP: 通过突变表型推断	28604741	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	28604741	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	28604741	GOA
located in focal adhesion	IDA IDA: 通过直接分析推断	20543869	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10564580	GOA
located in ruffle membrane	IDA IDA: 通过直接分析推断	20543869	GOA
located in stress fiber	IDA IDA: 通过直接分析推断	20543869	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAM107A 蛋白结构

DUF1151

0
100
144 a.a.

蛋白主名

其他名称

actin-associated protein FAM107A

down-regulated in renal cell carcinoma 1

关联疾病

疾病名称

别名

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式 Pre-designed Sets	纯度	是否罕见病否
HY-RS04676	FAM107A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FAM107A	RGD	RGD:1306327
Bos taurus	FAM107A	VGNC	VGNC:28713
Macaca mulatta	FAM107A	VGNC	VGNC:72416
Canis familiaris	FAM107A	VGNC	VGNC:40575
Mus musculus	FAM107A	MGD	MGI:3041256
Felis catus	FAM107A	VGNC	VGNC:62046

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAM107A - family with sequence similarity 107 member A Gene

关于 FAM107A

功能概要

FAM107A 基因产物(4)

FAM107A 蛋白结构

关联疾病

直系同源

热门区域

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FAM107A - family with sequence similarity 107 member A Gene

关于 FAM107A

功能概要

FAM107A 基因产物(4)

FAM107A 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z