2. Gene
  3. BAZ2A - bromodomain adjacent to zinc finger domain 2A Gene

BAZ2A - bromodomain adjacent to zinc finger domain 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：与锌指结构域 2A 相邻的溴结构域

种属: Homo sapiens

同用名: TIP5; WALp3

基因 ID: 11176 | 基因类型: protein coding

关于 BAZ2A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,595,596-56,638,318 (from NCBI)

This gene has 17 transcripts (splice variants), 216 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 26.6), placenta (RPKM 20.1) and 25 other tissues.

功能概要

启用组蛋白结合活动。有助于 RNA 聚合酶 I 核心启动子序列特异性 DNA 结合活性。预测参与 DNA 甲基化；组蛋白去乙酰化；和大分子代谢过程的负调控。预计在染色质组织和组蛋白修饰的上游或内部起作用。位于胞质溶胶和核斑点。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation; histone deacetylation; and negative regulation of macromolecule metabolic process. Predicted to act upstream of or within chromatin organization and histone modification. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

BAZ2A 基因产物(3)

mRNA Protein Name
NM_001300905.2 NP_001287834.1 bromodomain adjacent to zinc finger domain protein 2A isoform 2
NM_001351156.2 NP_001338085.1 bromodomain adjacent to zinc finger domain protein 2A isoform 3
NM_013449.4 NP_038477.2 bromodomain adjacent to zinc finger domain protein 2A isoform 1

BAZ2A 蛋白结构

MBD

MBD: Methyl-CpG binding domain (548 - 617)

DDT

DDT: DDT domain (849 - 910)

WHIM1

WHIM1: WSTF, HB1, Itc1p, MBD9 motif 1 (952 - 997)

(1439 - 1473)

PHD

PHD: PHD-finger (1679 - 1724)

Bromodomain

Bromodomain: Bromodomain (1802 - 1881)

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  • 1905 a.a.
蛋白主名 其他名称

bromodomain adjacent to zinc finger domain protein 2A

TTF-I interacting peptide 5

BAZ2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
BAZ2A Q9UIF9 Ttf1 Mus musculus Q62187
Y2H
11532953
种属内
BAZ2A Q9UIF9 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Spondylopathy

Inflammatory Spondylopathies In Disease Classified Elsewhere

Inflammatory Spondylopathies In Disease Ec

Inflammatory Spondylopathy In Disease Classified Elsewhere

Spondylitis
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2

SRTD2

Atd2

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15658 GSK2801 99.95% 否
HY-19336 BAZ2-ICR Inhibitor 99.95% 否
HY-107477 GSK8573 99.05% 否
HY-168448 dBAZ2 Degrader / 否
HY-168449 BAZ2A/B ligand 1 / 否
HY-168453 dBAZ2B Degrader / 否
HY-RS01379 BAZ2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus BAZ2A VGNC VGNC:69154
Macaca mulatta BAZ2A VGNC VGNC:70232
Mus musculus BAZ2A MGD MGI:2151152
Rattus norvegicus BAZ2A RGD RGD:1305037
Bos taurus BAZ2A VGNC VGNC:26430
Canis familiaris BAZ2A VGNC VGNC:38391
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