INMT - indolethylamine N-methyltransferase Gene

中文名称：吲哚乙胺 N-甲基转移酶

种属: Homo sapiens

同用名: TEMT

关于 INMT

功能概要

内源性和外源性化合物的 N-甲基化是它们降解的主要方法。该基因编码一种 N-甲基化吲哚如色胺的酶。可变剪接导致多个转录本变体。该基因与下游 MINDY4 (又名 FAM188B) 基因之间也存在通读转录。在啮齿类动物和其他哺乳动物 (例如鲸豚) 中，该基因的方向与其在人类和其他灵长类动物中的方向相反，并且该基因似乎在食肉动物和翼手目动物中丢失了。[RefSeq 提供，2019 年 7 月]

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an Enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and Other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and Other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]