1. Gene
  2. CHKA - choline kinase alpha Gene

CHKA - choline kinase alpha Gene

中文名称:胆碱激酶α

种属: Homo sapiens

同用名: CK; EK; CHK; CKI; NEDMIMS

基因 ID: 1119 | 基因类型: protein coding

关于 CHKA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,052,859-68,121,388 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues. Broad expression in testis (RPKM 24.3), thyroid (RPKM 9.0) and 25 other tissues.

功能概要

磷脂酰胆碱生物合成的主要途径是通过 CDP-胆碱途径发生的。该基因编码的蛋白质是序列中的起始酶,可能起到调节作用。编码的蛋白质还催化乙醇胺的磷酸化。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2008 年 7 月]

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial Enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CHKA 基因产物(6)

mRNA Protein Name
NM_001277.3 NP_001268.2 choline kinase alpha isoform a
NM_001376219.1 NP_001363148.1 choline kinase alpha isoform c
NM_001376220.1 NP_001363149.1 choline kinase alpha isoform d
NM_001376221.1 NP_001363150.1 choline kinase alpha isoform e
NM_001376222.1 NP_001363151.1 choline kinase alpha isoform f
NM_212469.2 NP_997634.1 choline kinase alpha isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables choline kinase activity IDA
IDA: 通过直接分析推断
19915674 GOA
enables ethanolamine kinase activity IDA
IDA: 通过直接分析推断
19915674 GOA
enables protein binding IDA
IDA: 通过直接分析推断
34077757 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
34077757 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
34077757 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
34077757 GOA
acts upstream of positive effect lipid droplet disassembly IDA
IDA: 通过直接分析推断
34077757 GOA
involved in phosphatidylcholine biosynthetic process IDA
IDA: 通过直接分析推断
19915674 GOA
involved in phosphatidylethanolamine biosynthetic process IDA
IDA: 通过直接分析推断
19915674 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
19915674 GOA
located in lipid droplet IDA
IDA: 通过直接分析推断
34077757 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CHKA 蛋白结构

Choline_kinase

Choline_kinase: Choline/ethanolamine kinase (139 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
蛋白主名 其他名称

choline kinase alpha

CHETK-alpha

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures

NEDMIMS

Muscular Lipidosis

Lipid Storage Myopathy

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Neuroleptic Malignant Syndrome
Cecal Benign Neoplasm

Cecal Neoplasms

Cecum Neoplasm

Neoplasm Of Caecum

Cecal Neoplasm

Cecum Carcinoma

Malignant Neoplasm Of Cecum

Cecum Adenoma

Caecum Adenoma

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Pycnodysostosis

Pyknodysostosis

PKND

Pycd

Toulouse-Lautrec Syndrome

Liver Rhabdomyosarcoma

Rhabdomyosarcoma Of Liver

Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach

Muscular Dystrophy, Congenital, Megaconial Type

Megaconial Type Congenital Muscular Dystrophy

Congenital Megaconial Myopathy

Congenital Muscular Dystrophy Due To Phosphatidylcholine Biosynthesis Defect

Congenital Muscular Dystrophy With Mitochondrial Structural Abnormalities

Megaconial Congenital Muscular Dystrophy

MDCMC

Muscular Dystrophy, Congenital, With Mitochondrial Structural Abnormalities

Megaconial Congénital Muscular Dystrophy

Dystrophy, Muscular, Congenital, Megaconial Type

Myopathy

Muscular Diseases

Myopathies

Hemoglobin D Disease

Hb-D Disease

Punjab Disease

Los Angeles Disease

Hb D Los Angeles Disease

Hb D Punjab Disease

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Joubert Syndrome 32

JBTS32

Choline Deficiency Disease

Choline Deficiency

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Microinvasive Gastric Cancer

Early Gastric Cancer

Surface Gastric Cancer

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency

Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CHKA VGNC VGNC:60860
Macaca mulatta CHKA VGNC VGNC:71039
Mus musculus CHKA MGD MGI:107760
Rattus norvegicus CHKA RGD RGD:61944
Canis familiaris CHKA VGNC VGNC:39218
Bos taurus CHKA VGNC VGNC:27295