GALNT6 - polypeptide N-acetylgalactosaminyltransferase 6 Gene

中文名称：多肽 N-乙酰半乳糖氨基转移酶 6

种属: Homo sapiens

同用名: GalNAcT6; GALNAC-T6

关于 GALNT6

功能概要

该基因编码 UDP-N-乙酰基-α-D-半乳糖胺：多肽 N-乙酰半乳糖胺基转移酶 (GalNAc-T) 酶家族的成员。 GalNAc-Ts 通过催化 GalNAc 转移到靶蛋白上的丝氨酸和苏氨酸残基，在高尔基体中启动粘蛋白型 O-连接糖基化。它们的特征在于 N 末端跨膜结构域、茎区、含有 GT1 基序和 Gal/GalNAc 转移酶基序的腔催化结构域，以及 C 末端蓖麻蛋白/凝集素样结构域。 GalNAc-T 具有不同但重叠的底物特异性和表达模式。编码的蛋白能够在体外糖基化纤连蛋白肽，并在成纤维细胞系中表达，表明它可能参与癌胚纤连蛋白的合成。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of Enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]