ZHX1 - zinc fingers and homeoboxes 1 Gene

中文名称：锌指和同源盒 1

种属: Homo sapiens

关于 ZHX1

功能概要

锌指和同源框基因家族的成员是与核因子-Y (NF-YA) 的 A 亚基相互作用的核同源二聚体转录抑制因子，包含两个 C2H2 型锌指和五个同源框 DNA 结合域。该基因编码该基因家族的成员 1。除了形成同源二聚体之外，该蛋白质还与锌指和同源框家族的成员 2 和 3 异源二聚化。可变剪接导致多个转录本变体。该基因与下游 8 号染色体开放阅读框 76 (C8orf76) 基因之间也存在通读转录。[RefSeq 提供，2011 年 2 月]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]