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  2. LYPLA2 - lysophospholipase 2 Gene

LYPLA2 - lysophospholipase 2 Gene

中文名称:溶血磷脂酶 2

种属: Homo sapiens

同用名: APT2; APT-2; DJ886K2.4

基因 ID: 11313 | 基因类型: protein coding

关于 LYPLA2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,791,145-23,795,539 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues.

功能概要

溶血磷脂酶是作用于生物膜以调节多功能溶血磷脂的酶。描述了该基因的选择性剪接转录变体,但全长性质尚不清楚。[RefSeq 提供,2008 年 7 月]

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

LYPLA2 基因产物(1)

mRNA Protein Name
NM_007260.3 NP_009191.1 acyl-protein thioesterase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lysophospholipase activity IDA
IDA: 通过直接分析推断
25301951 GOA
enables palmitoyl-(protein) hydrolase activity IDA
IDA: 通过直接分析推断
28826475 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acylglycerol catabolic process IDA
IDA: 通过直接分析推断
25301951 GOA
involved in prostaglandin catabolic process IDA
IDA: 通过直接分析推断
25301951 GOA
involved in protein depalmitoylation IDA
IDA: 通过直接分析推断
28826475 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25468996 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LYPLA2 蛋白结构

Abhydrolase_2

Abhydrolase_2: Phospholipase/Carboxylesterase (13 - 227)

  • 0
  • 100
  • 200
  • 231 a.a.
蛋白主名 其他名称

acyl-protein thioesterase 2

LPL-II

LYPLA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86 32296183
种属内
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86 32296183
种属内
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LYPLA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70221 Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His) O95372 (M1-V231) ≥95%

关联疾病

疾病名称 别名
Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease

2p21 Microdeletion Syndrome

HCS

Homozygous 2p16 Deletion Syndrome, Formerly

2p21 Deletion Syndrome

Del(2)(P21)

Monosomy 2p21

Atypical Hypotonia-Cystinuria Syndrome

Atypical Hcs

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus LYPLA2 MGD MGI:1347000
Macaca mulatta LYPLA2 VGNC VGNC:74465
Canis familiaris LYPLA2 VGNC VGNC:42891
Felis catus LYPLA2 VGNC VGNC:68112
Bos taurus LYPLA2 VGNC VGNC:31106
Rattus norvegicus LYPLA2 RGD RGD:620210
Others LYPLA2 NCBI