1. Gene
  2. CDCA5 - cell division cycle associated 5 Gene

CDCA5 - cell division cycle associated 5 Gene

中文名称:细胞分裂周期相关 5

种属: Homo sapiens

同用名: SORORIN

基因 ID: 113130 | 基因类型: protein coding

关于 CDCA5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,061,093-65,084,040 (from NCBI)

This gene has 10 transcripts (splice variants) and 170 orthologues. Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues.

功能概要

预测启用染色质结合活性。参与双链断裂修复;有丝分裂姐妹染色单体分离;和细胞周期过程的调节。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDCA5 基因产物(1)

mRNA Protein Name
NM_080668.4 NP_542399.1 sororin
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21111234 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15837422 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair IMP
IMP: 通过突变表型推断
17349791 GOA
involved in mitotic cell cycle IDA
IDA: 通过直接分析推断
15837422 GOA
involved in mitotic chromosome condensation IMP
IMP: 通过突变表型推断
15837422 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
15837422 GOA
involved in mitotic sister chromatid cohesion IMP
IMP: 通过突变表型推断
17349791 GOA
involved in mitotic sister chromatid cohesion IPI
IPI: 通过物理相互作用推断
21111234 GOA
involved in positive regulation of exit from mitosis IMP
IMP: 通过突变表型推断
23548868 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDCA5 蛋白结构

Sororin

Sororin: Sororin protein (89 - 215)

  • 0
  • 100
  • 200
  • 252 a.a.
蛋白主名 其他名称

sororin

cell division cycle-associated protein 5

关联疾病

疾病名称 别名
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome

Sc Phocomelia Syndrome

RBS

Long Bone Deficiencies Associated With Cleft Lip-Palate

Sc Pseudothalidomide Syndrome

Appelt-Gerken-Lenz Syndrome

Pseudothalidomide Syndrome

Tetraphocomelia-Cleft Palate Syndrome

Hypomelia Hypotrichosis Facial Hemangioma Syndrome

Roberts Syndrome/Sc Phocomelia

Roberts Tetraphocomelia Syndrome

Sc Syndrome

Sc Phocomelia

Sc Disease

Sc

Hemoglobin Sc Disease

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation

Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

FLPIS

Scott Bryant Graham Syndrome

Craniodigital-Intellectual Disability Syndrome

Scott Craniodigital Syndrome

Scott-Bryant-Graham Syndrome

Syndactyly, Type I, With Microcephaly And Mental Retardation

Syndactyly Type I With Microcephaly And Intellectual Disability

Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

Craniodigital Syndrome With Intellectual Disability

Craniodigital Syndrome-Intellectual Disability Syndrome

Craniodigital Syndrome-Intellectual Disability, Scott Type

Intellectual Disability-Craniodigital Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CDCA5 VGNC VGNC:39015
Felis catus CDCA5 VGNC VGNC:60667
Bos taurus CDCA5 VGNC VGNC:56261
Mus musculus CDCA5 MGD MGI:1915099
Rattus norvegicus CDCA5 RGD RGD:1560863
Macaca mulatta CDCA5 VGNC VGNC:100907