PHB2 - prohibitin 2 Gene

中文名称：抑制素 2

种属: Homo sapiens

同用名: BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141

基因 ID: 11331 | 基因类型: protein coding

关于 PHB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,965,327-6,970,753 (from NCBI)

This gene has 20 transcripts (splice variants), 251 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 111.2), duodenum (RPKM 62.9) and 25 other tissues.

功能概要

启用多种功能，包括蛋白质 C 末端结合活性；蛋白质 N-末端结合活性；和蛋白质二聚化活性。参与多个过程，包括对病毒的防御反应；细胞周期相变的正调控；和转录调控，DNA 模板化。位于多个细胞成分中，包括细胞表面；线粒体膜；和核基质。线粒体抑制素复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022]

PHB2 基因产物(2)

mRNA	Protein	Name
NM_001144831.2	NP_001138303.1	prohibitin-2 isoform 1
NM_001267700.1	NP_001254629.1	prohibitin-2 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables amide binding	IPI IPI: 通过物理相互作用推断	19116139	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	31522117	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10359819	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	28017329	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	31522117	GOA
enables sphingolipid binding	IDA IDA: 通过直接分析推断	20959514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RIG-I signaling pathway	IDA IDA: 通过直接分析推断	31522117	GOA
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	31522117	GOA
involved in cell migration	IDA IDA: 通过直接分析推断	24003225	GOA
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	17008324	GOA
involved in mitophagy	IDA IDA: 通过直接分析推断	28017329	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	18629613	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10359819	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	17008324	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	18629613	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	22417827	GOA
NOT involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	24003225	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: 通过突变表型推断	23548868	GOA
involved in positive regulation of exit from mitosis	IMP IMP: 通过突变表型推断	23548868	GOA
involved in protein import into nucleus	IDA IDA: 通过直接分析推断	17008324	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	18339324	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	17008324	GOA
NOT involved in regulation of complement activation	IDA IDA: 通过直接分析推断	17070910	GOA
involved in regulation of cytochrome-c oxidase activity	IMP IMP: 通过突变表型推断	20959514	GOA
involved in sister chromatid cohesion	IDA IDA: 通过直接分析推断	23548868	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell periphery	IDA IDA: 通过直接分析推断	19906925	GOA
located in cell surface	IDA IDA: 通过直接分析推断	22417827	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19116139	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	18339324	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	17008324	GOA
part of mitochondrial prohibitin complex	IDA IDA: 通过直接分析推断	31522117	GOA
part of mitochondrial prohibitin complex	IPI IPI: 通过物理相互作用推断	20959514	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	19906925	GOA
located in nuclear matrix	IDA IDA: 通过直接分析推断	21328542	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17008324	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	22997079	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	21328542	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHB2 蛋白结构

Band_7

0
100
200
299 a.a.

蛋白主名

其他名称

prohibitin-2

B cell receptor associated protein 37

PHB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Y2H Pooling	32814053
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Validated Y2H	32814053
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Y2H Array	32814053
Intra	PHB2	Q99623	ESR1	Homo sapiens	P03372	Pull Down	10359819
Intra	PHB2	Q99623	ESR1	Homo sapiens	P03372	Y2H	10359819

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Breast Medullary Carcinoma

Medullary Breast Carcinoma	Medullary Breast Carcinoma With Lymphoid Stroma
Medullary Carcinoma Of Breast

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114989	Fluorizoline	Inducer	99.77%	否
HY-152093	YL-939	Inhibitor	98.97%	否
HY-117113	JI051	Inhibitor	≥98.0%	否
HY-124484	JI130	Inhibitor	99.01%	否
HY-162904	BPU17		/	否
HY-RS10408	PHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PHB2	VGNC	VGNC:44476
Macaca mulatta	PHB2	VGNC	VGNC:100088
Bos taurus	PHB2	VGNC	VGNC:32809
Felis catus	PHB2	VGNC	VGNC:64132
Rattus norvegicus	PHB2	RGD	RGD:620203
Mus musculus	PHB2	MGD	MGI:102520
Macaca fascicularis	PHB2	NCBI	NCBI:102136314
Others	PHB2	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PHB2 - prohibitin 2 Gene

关于 PHB2

功能概要

PHB2 基因产物(2)

PHB2 蛋白结构

PHB2 蛋白互作信息

关联疾病

直系同源

热门区域

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PHB2 - prohibitin 2 Gene

关于 PHB2

功能概要

PHB2 基因产物(2)

PHB2 蛋白结构

PHB2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z