1. Gene
  2. UCN3 - urocortin 3 Gene

UCN3 - urocortin 3 Gene

中文名称:尿皮质素 3

种属: Homo sapiens

同用名: SCP; SPC; UCNIII

基因 ID: 114131 | 基因类型: protein coding

关于 UCN3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,364,966-5,374,692 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 1 paralogue. Biased expression in duodenum (RPKM 4.8), small intestine (RPKM 3.4) and 8 other tissues.

功能概要

该基因编码 sauvagine/促肾上腺皮质激素释放因子/urotensin I 蛋白家族的成员。编码的前原蛋白经过蛋白水解处理,产生成熟的肽激素,由胰腺 β 和 α 细胞分泌。这种激素是促肾上腺皮质激素释放因子受体 2 的内源性配体,可根据血浆葡萄糖水平调节胰岛素分泌。 2 型糖尿病患者表现出 β 细胞中编码蛋白水平降低。在大脑中,编码的蛋白质可能是压力对食欲影响的原因。[RefSeq 提供,2016 年 5 月]

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate Insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

UCN3 基因产物(1)

mRNA Protein Name
NM_053049.4 NP_444277.2 urocortin-3 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables corticotropin-releasing hormone receptor binding IPI
IPI: 通过物理相互作用推断
11329063 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20966082 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11329063 GOA
involved in hormone-mediated signaling pathway IDA
IDA: 通过直接分析推断
11329063 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UCN3 蛋白结构

(120 - 157)

  • 0
  • 100
  • 161 a.a.
蛋白主名 其他名称

urocortin-3

prepro-urocortin 3

关联疾病

疾病名称 别名
Mixed Sleep Apnea

Complex Sleep Apnea

Sleep Apnea, Mixed Central And Obstructive

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UCN3 VGNC VGNC:79090
Bos taurus UCN3 VGNC VGNC:36639
Mus musculus UCN3 MGD MGI:1932970
Canis familiaris UCN3 VGNC VGNC:48110
Felis catus UCN3 VGNC VGNC:82339
Rattus norvegicus UCN3 RGD RGD:1562213