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  2. Mtnr1a - melatonin receptor 1A Gene

Mtnr1a - melatonin receptor 1A Gene

中文名称:褪黑激素受体 1A

种属: Rattus norvegicus

基因 ID: 114211 | 基因类型: protein coding

关于 Mtnr1a

Primary_assembly 16: 47,144,461-47,163,919 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 185 orthologues, 50 paralogues and is associated with 7 phenotypes. Biased expression in Uterus (RPKM 4.2), Adrenal (RPKM 1.1) and 1 other tissue.

功能概要

预测该基因编码的蛋白可启动激素结合活性;褪黑激素受体活性;和有机环状化合物结合活性。涉及多个过程,包括照相机式眼睛的发育;昼夜节律;和胰岛素分泌的负调节。位于神经细胞体中。 2 型糖尿病的生物标志物。与人类 MTNR1A(褪黑激素受体 1A)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable hormone binding activity; Melatonin Receptor activity; and organic cyclic compound binding activity. Involved in several processes, including camera-type eye development; circadian rhythm; and negative regulation of Insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (Melatonin Receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1a 基因产物(1)

mRNA Protein Name
NM_053676.2 NP_446128.1 melatonin receptor type 1A
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in camera-type eye development IEP
IEP: 通过表达模式推断
12890503 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23895529 RGD
involved in negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
22288848 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body IDA
IDA: 通过直接分析推断
10465462 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mtnr1a 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (30 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (32 - 56)

7tm_GPCRs

7tm_GPCRs: cd14964 (65 - 87)

7tm_GPCRs

7tm_GPCRs: cd14964 (103 - 125)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (187 - 210)

7tm_GPCRs

7tm_GPCRs: cd14964 (239 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

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  • 100
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  • 300
  • 353 a.a.
蛋白主名 其他名称

melatonin receptor type 1A

mel-1A-R

mel1a melatonin receptor

mel1a receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mtnr1a NCBI NCBI:4543