2. Gene
  3. Chek2 - checkpoint kinase 2 Gene

Chek2 - checkpoint kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：检查点激酶 2

种属: Rattus norvegicus

同用名: Chk2; Rad53

基因 ID: 114212 | 基因类型: protein coding

关于 Chek2

Primary_assembly 12: 45,788,827-45,821,286 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 206 orthologues and is associated with 61 phenotypes. Biased expression in Thymus (RPKM 6.6), Spleen (RPKM 55.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。涉及多个过程，包括细胞对双酚 A 的反应；失巢凋亡的正向调节；和细胞周期相变的调节。位于核内。膀胱癌的生物标志物。该基因的人类直系同源物与多种疾病有关，包括 Li-Fraumeni 综合征 2；乳腺癌（多发性）；结直肠癌；骨肉瘤;和前列腺癌。与人类 CHEK2（检查点激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Located in nucleus. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Chek2 基因产物(1)

mRNA Protein Name
NM_053677.1 NP_446129.1 serine/threonine-protein kinase Chk2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase activity IDA
IDA: 通过直接分析推断
10435585 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19812253 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
11278490 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10435585 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
10435585 RGD
involved in cellular response to bisphenol A IEP
IEP: 通过表达模式推断
25344109 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
21745814 RGD
involved in negative regulation of DNA damage checkpoint IMP
IMP: 通过突变表型推断
20637979 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
10435585 RGD
involved in positive regulation of anoikis IMP
IMP: 通过突变表型推断
21834075 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
18162465 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18162465 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11278490 RGD
involved in response to glycoside IEP
IEP: 通过表达模式推断
19801496 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Chek2 蛋白结构

FHA_CHK2

FHA_CHK2: cd22666 (95 - 206)

STKc_Chk2

STKc_Chk2: cd14084 (215 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Chk2

CHK2 checkpoint homolog

protein kinase Chk2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02619 CHEK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02620 Chek2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02621 Chek2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chek2 NCBI NCBI:11200
Mus musculus Chek2 NCBI NCBI:50883
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