1. Gene
  2. TUBGCP5 - tubulin gamma complex associated protein 5 Gene

TUBGCP5 - tubulin gamma complex associated protein 5 Gene

中文名称:微管蛋白γ复合体相关蛋白 5

种属: Homo sapiens

同用名: GCP5

基因 ID: 114791 | 基因类型: protein coding

关于 TUBGCP5

Cytogenetic location: 15q11.2 Genomic coordinates (GRCh38): 15:22,983,025-23,039,569 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 205 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues.

功能概要

启用微管结合活动。参与微管成核。位于中心体和细胞质中。 γ-微管蛋白大复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]

TUBGCP5 基因产物(9)

mRNA Protein Name
NM_001102610.2 NP_001096080.1 gamma-tubulin complex component 5 isoform b
NM_001354372.2 NP_001341301.1 gamma-tubulin complex component 5 isoform c
NM_001354373.2 NP_001341302.1 gamma-tubulin complex component 5 isoform d
NM_001354374.2 NP_001341303.1 gamma-tubulin complex component 5 isoform e
NM_001354375.2 NP_001341304.1 gamma-tubulin complex component 5 isoform f
NM_001354376.2 NP_001341305.1 gamma-tubulin complex component 5 isoform g
NM_001354377.2 NP_001341306.1 gamma-tubulin complex component 5 isoform h
NM_001354378.2 NP_001341307.1 gamma-tubulin complex component 5 isoform i
NM_052903.6 NP_443135.3 gamma-tubulin complex component 5 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
11694571 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in microtubule nucleation IDA
IDA: 通过直接分析推断
11694571 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
part of gamma-tubulin ring complex IDA
IDA: 通过直接分析推断
11694571 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TUBGCP5 蛋白结构

Spc97_Spc98

Spc97_Spc98: Spc97 / Spc98 family (273 - 942)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1024 a.a.
蛋白主名 其他名称

gamma-tubulin complex component 5

gamma-tubulin complex component GCP5

TUBGCP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TUBGCP5 Q96RT8 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 25

Cataract, Central Saccular, With Sutural Opacities

CTRCT25

Ccsso

Cataract, Central Pouch-Like, With Sutural Opacities

Central Pouch-Like Cataract With Sutural Opacities

Central Saccular Cataract With Sutural Opacities

Early-Onset Cataract With Y-Shaped Suture Opacities

Spastic Paraplegia 6, Autosomal Dominant

SPG6

Fsp3

Hereditary Spastic Paraplegia 6

Autosomal Dominant Spastic Paraplegia Type 6

Spastic Paraplegia 6

Familial Spastic Paraplegia Autosomal Dominant 3

Familial Spastic Paraplegia, Autosomal Dominant, 3

Autosomal Dominant Familial Spastic Paraplegia Type 3

Autosomal Dominant Spastic Paraplegia 6

Spastic Paraplegia-6

Paraplegia, Spastic, Type 6

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Chromosome 15q11.2 Deletion Syndrome

15q11.2 Microdeletion Syndrome

15q11.2 Bp1-Bp2 Microdeletion Syndrome

Del(15)(Q11.2)

Monosomy 15q11.2

15q11.2 Microdeletion

Chromosome 15q11.2 Deletion

Chromosome 15q11.2 Microdeletion

Chromosome Deletion Syndrome 15q11.2

Microdeletion 15q11.2

Duplication 15q11-Q13 Syndrome

Dyscalculia

Disorder Of Arithmetical Skills

Mathematics Disorder

Developmental Arithmetic Disorder

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM

Precocious Puberty, Central, 2

CPPB2

Central Precocious Puberty 2

Precocious Puberty, Central 2

Precocious Puberty, Central, Type 2

Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Childhood Absence Epilepsy

Pyknolepsy

Petit Mal Epilepsy

Absence Seizures

Absence Seizure

Petit Mal Seizure

Absence Epilepsy, Childhood

Pykno-Epilepsy

Epilepsy, Absence

Absence Epilepsy

Pycnolepsy

Dyslexia
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TUBGCP5 VGNC VGNC:79155
Bos taurus TUBGCP5 VGNC VGNC:36515
Rattus norvegicus TUBGCP5 RGD RGD:1304689
Mus musculus TUBGCP5 MGD MGI:2178836
Canis familiaris TUBGCP5 VGNC VGNC:47995
Felis catus TUBGCP5 VGNC VGNC:66707