Acvr2b - activin receptor IIB Gene

中文名称：激活素受体 IIB

种属: Mus musculus

同用名: ActRIIB; AI047905; 4930516B21Rik

关于 Acvr2b

功能概要

激活激活素结合活动；生长因子结合活性；和蛋白激酶活性。参与血管重塑；冷诱导产热的负调节；和血管发育。作用于多个过程的上游或内部，包括动物器官发育；胚胎形态发生；和胰岛素分泌。预计位于细胞质中。预计是激活素受体复合物的一部分。预计在质膜上有活性。以多种结构表达，包括消化系统；蛋筒；泌尿生殖系统；神经系统;和感觉器官。用于研究右心房异构和内脏异位。该基因的人类直系同源物与内脏异源性有关。与人类 ACVR2B（2B 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and Insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]