Acvrl1 - activin A receptor, type II-like 1 Gene

中文名称：激活素 A 受体， II 型样 1

种属: Mus musculus

同用名: Alk1; Acvrlk1

关于 Acvrl1

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动；激活素结合活性；和跨膜受体蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括调节内皮细胞分化；调节内皮细胞增殖；和血管发育。作用于多个过程的上游或内部，包括血管生成；血管生成的正向调节；和跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路。预测位于细胞表面；树突;和神经细胞体。预计是质膜的组成部分。预计是 BMP 受体复合物的一部分。预计在质膜上有活性。以多种结构表达，包括消化系统；中枢神经系统;眼睛;泌尿生殖系统；和免疫系统。用于研究大脑的动静脉畸形和遗传性出血性毛细血管扩张症。该基因的人类直系同源物与遗传性出血性毛细血管扩张症和肺动脉高压有关。与人类 ACVRL1（1 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including regulation of endothelial cell differentiation; regulation of endothelial cell proliferation; and vasculature development. Acts upstream of or within several processes, including angiogenesis; positive regulation of angiogenesis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in cell surface; dendrite; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of BMP Receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (Activin A receptor like type 1). [provided by Alliance of Genome Resources, Apr 2022]