Ada - adenosine deaminase Gene

中文名称：腺苷脱氨酶

种属: Mus musculus

关于 Ada

功能概要

该基因编码的蛋白可启动 2'-脱氧腺苷脱氨酶活性；腺苷脱氨酶活性；和锌离子结合活性。参与尿囊素代谢过程和嘌呤核苷一磷酸代谢过程。作用于多个过程的上游或内部，包括动物器官发育；含核碱基的小分子代谢过程；和淋巴细胞活化的正调节。位于细胞质中。在胞质溶胶中有活性。以多种结构表达，包括消化系统；脑;胚外成分；泌尿生殖系统；和感觉器官。用于研究腺苷脱氨酶缺乏症。该基因的人类直系同源物与腺苷脱氨酶缺乏症有关；哮喘;和严重的联合免疫缺陷。与人类 ADA（腺苷脱氨酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 2'-deoxyadenosine deaminase activity; Adenosine Deaminase activity; and zinc ion binding activity. Involved in allantoin metabolic process and purine nucleoside monophosphate metabolic process. Acts upstream of or within several processes, including animal organ development; nucleobase-containing small molecule metabolic process; and positive regulation of lymphocyte activation. Located in cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study Adenosine Deaminase deficiency. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]