2. Gene
  3. Ada - adenosine deaminase Gene

Ada - adenosine deaminase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：腺苷脱氨酶

种属: Rattus norvegicus

基因 ID: 24165 | 基因类型: protein coding

关于 Ada

Primary_assembly 3: 152,398,747-152,447,088 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Lung (RPKM 737.7), Thymus (RPKM 689.8) and 7 other tissues.

功能概要

该基因编码的蛋白可启动腺苷脱氨酶活性和嘌呤核苷结合活性。参与多个过程，包括腺苷代谢过程；昼夜节律睡眠/觉醒周期的负调节，非快速眼动睡眠；和对维生素E的反应。位于树突细胞质中；细胞外空间；和神经细胞体。用于研究高血压；腹膜炎;和肺水肿。高血糖生物标志物；钩端螺旋体病;肺部疾病;和锥虫病。该基因的人类直系同源物与腺苷脱氨酶缺乏症有关；哮喘;和严重的联合免疫缺陷。与人类 ADA（腺苷脱氨酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Adenosine Deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada 基因产物(1)

mRNA Protein Name
NM_130399.2 NP_569083.1 adenosine deaminase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenosine deaminase activity IDA
IDA: 通过直接分析推断
3746429 RGD
enables purine nucleoside binding IDA
IDA: 通过直接分析推断
3746429 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine catabolic process IMP
IMP: 通过突变表型推断
30269308 RGD
involved in adenosine metabolic process IDA
IDA: 通过直接分析推断
3746429 RGD
involved in histamine secretion IMP
IMP: 通过突变表型推断
19066225 RGD
involved in negative regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: 通过突变表型推断
19066225 RGD
involved in regulation of T cell differentiation in thymus IMP
IMP: 通过突变表型推断
3876160 RGD
involved in regulation of circadian sleep/wake cycle, sleep IEP
IEP: 通过表达模式推断
11038259 RGD
involved in response to L-arginine IEP
IEP: 通过表达模式推断
22623885 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
27491636 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
15966013 RGD
involved in response to hypoxia IMP
IMP: 通过突变表型推断
20735412 RGD
involved in response to vitamin E IDA
IDA: 通过直接分析推断
16716042 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16716042 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite cytoplasm IDA
IDA: 通过直接分析推断
2253038 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16563876 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
2253038 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ada 蛋白结构

A_deaminase

A_deaminase: pfam00962 (9 - 348)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
蛋白主名 其他名称

adenosine deaminase

adenosine aminohydrolase

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-17377 Vicriviroc maleate 99.91% Phase 3
HY-105017 Evodenoson Agonist 99.74% Phase 2
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103160A EHNA hydrochloride Inhibitor 99.61% 否
HY-W011552 2'-O-Methyladenosine 99.44% 否
HY-N7368 Hibifolin Inhibitor 99.70% 否
HY-158009 SGF29-IN-1 Inhibitor ≥98.0% 否
HY-116578 Metopimazine 98.03% 否
HY-103237 L-Adenosine Inhibitor ≥97.0% 否
HY-N6689 Destruxin A 97.92% 否
HY-103159 1-Deazaadenosine Inhibitor ≥98.0% 否
HY-114175A Adenosine deaminase, Calf Spleen / 否
HY-D0855A ADA disodium ≥98.0% 否
HY-D0855 ADA ≥97.0% 否
HY-W753672 2'-O-Methyladenosine-d3 / 否
HY-117260 Coformycin Inhibitor / 否
HY-P5201S VTSEGAGLQLQK-13C6,15N2 / 否
HY-RS00258 ADA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00259 Ada Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00260 Ada Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00261 ADA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W129499 ADA sodium / 否
HY-137294 BTPTT-4F / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ada NCBI NCBI:100
Macaca fascicularis Ada NCBI NCBI:102137458
Mus musculus Ada NCBI NCBI:11486
Macaca mulatta Ada NCBI NCBI:717897
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