Ada - adenosine deaminase Gene

中文名称：腺苷脱氨酶

种属: Rattus norvegicus

关于 Ada

功能概要

该基因编码的蛋白可启动腺苷脱氨酶活性和嘌呤核苷结合活性。参与多个过程，包括腺苷代谢过程；昼夜节律睡眠/觉醒周期的负调节，非快速眼动睡眠；和对维生素E的反应。位于树突细胞质中；细胞外空间；和神经细胞体。用于研究高血压；腹膜炎;和肺水肿。高血糖生物标志物；钩端螺旋体病;肺部疾病;和锥虫病。该基因的人类直系同源物与腺苷脱氨酶缺乏症有关；哮喘;和严重的联合免疫缺陷。与人类 ADA（腺苷脱氨酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Adenosine Deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]