OSBPL8 - oxysterol binding protein like 8 Gene

中文名称：氧固醇结合蛋白 8

种属: Homo sapiens

同用名: ORP8; MST120; OSBP10; MSTP120

关于 OSBPL8

功能概要

该基因编码一个蛋白质家族的成员，该蛋白质家族包含一个 N 末端 pleckstrin 同源结构域和一个高度保守的 C 末端氧固醇结合蛋白样固醇结合结构域。它结合多种含脂质分子，包括磷脂酰丝氨酸、磷脂酰肌醇 4-磷酸 (PI4P) 和氧固醇，并促进它们在内质网和质膜之间的交换。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]