C1QTNF1 - C1q and TNF related 1 Gene

中文名称：C1q 和 TNF 相关 1

种属: Homo sapiens

同用名: GIP; CTRP1; ZSIG37

基因 ID: 114897 | 基因类型: protein coding

关于 C1QTNF1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,022,934-79,049,788 (from NCBI)

This gene has 12 transcripts (splice variants), 160 orthologues and 23 paralogues. Broad expression in fat (RPKM 33.8), placenta (RPKM 15.4) and 21 other tissues.

功能概要

启用胶原蛋白结合活性。参与多个过程，包括血小板聚集的负调节；醛固酮分泌的正调节；和细胞溶质钙离子浓度的正调节。位于细胞外空间。是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity. Involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF1 基因产物(4)

mRNA	Protein	Name
NM_030968.5	NP_112230.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_153372.3	NP_699203.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_198593.4	NP_940995.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_198594.4	NP_940996.1	complement C1q tumor necrosis factor-related protein 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables collagen binding	IDA IDA: 通过直接分析推断	16195328	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12409230	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of platelet activation	IDA IDA: 通过直接分析推断	16195328	GOA
involved in negative regulation of platelet aggregation	IDA IDA: 通过直接分析推断	16195328	GOA
involved in positive regulation of aldosterone secretion	IDA IDA: 通过直接分析推断	18171693	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	18171693	GOA
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	18171693	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	18171693	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12409230	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

C1QTNF1 蛋白结构

Collagen

C1q

0
100
200
281 a.a.

蛋白主名

其他名称

complement C1q tumor necrosis factor-related protein 1

C1q and tumor necrosis factor related protein 1

重组 C1QTNF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7693	C1QTNF1/CTRP1 Protein, Human (HEK293, His)	Q9BXJ1-1 (R26-P281)	≥95%

关联疾病

疾病名称

别名

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Chorioangioma

Placental Hemangioma

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01726	C1QTNF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	C1QTNF1	RGD	RGD:1359204
Mus musculus	C1QTNF1	MGD	MGI:1919254
Canis familiaris	C1QTNF1	VGNC	VGNC:51925
Macaca mulatta	C1QTNF1	VGNC	VGNC:70311
Felis catus	C1QTNF1	VGNC	VGNC:60221
Bos taurus	C1QTNF1	VGNC	VGNC:26622
Others	C1QTNF1	NCBI

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