2. Gene
  3. CIDEA - cell death inducing DFFA like effector a Gene

CIDEA - cell death inducing DFFA like effector a Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞死亡诱导 DFFA 样效应物 a

种属: Homo sapiens

同用名: CIDE-A

基因 ID: 1149 | 基因类型: protein coding

关于 CIDEA

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,254,361-12,277,595 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Restricted expression toward fat (RPKM 78.2).

功能概要

该基因编码小鼠蛋白 Cidea 的同系物，该蛋白已被证明可激活细胞凋亡。这种细胞凋亡的激活受到 DNA 片段化因子 DFF45 的抑制，但不受 Caspase 抑制剂的抑制。缺乏功能性 Cidea 的小鼠在受到寒冷时具有更高的代谢率、棕色脂肪组织中更高的脂肪分解和更高的核心体温。这些老鼠也能抵抗饮食引起的肥胖和糖尿病。这表明在小鼠中，该基因产物在产热和脂肪分解中发挥作用。已经鉴定出选择性剪接的转录物。[RefSeq 提供，2010 年 8 月]

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate Apoptosis. This activation of Apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by Caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

CIDEA 基因产物(2)

mRNA Protein Name
NM_001279.4 NP_001270.1 cell death activator CIDE-A isoform 1
NM_001318383.2 NP_001305312.1 cell death activator CIDE-A isoform 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid droplet fusion IDA
IDA: 通过直接分析推断
19843876 GOA
involved in lipid storage IDA
IDA: 通过直接分析推断
19843876 GOA
involved in negative regulation of cytokine production IMP
IMP: 通过突变表型推断
15919794 GOA
involved in negative regulation of lipid catabolic process IDA
IDA: 通过直接分析推断
26118629 GOA
involved in negative regulation of lipid catabolic process IMP
IMP: 通过突变表型推断
15919794 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
15919794 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with lipid droplet IDA
IDA: 通过直接分析推断
18509062 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CIDEA 蛋白结构

CIDE-N

CIDE-N: CIDE-N domain (34 - 109)

  • 0
  • 100
  • 200
  • 219 a.a.
蛋白主名 其他名称

cell death activator CIDE-A

关联疾病

疾病名称 别名
Lipomatosis, Multiple Symmetric

Multiple Symmetric Lipomatosis

Lipomatosis, Familial Benign Cervical

Lipomatosis, Multiple Symmetrical

Lipodystrophy, Cephalothoracic

Benign Symmetrical Lipomatosis

Madelung Disease

Madelung'S Disease

MSL

Cervical Symmetrical Lipomatosis

Launois-Bensaude'S Lipomatosis

Madelung'S Neck

Multiple Symmetrical Lipomatosis

Familial Symmetric Lipomatosis

Launois-Bensaude Syndrome

Cephalothoracic Lipodystrophy

Familial Benign Cervical Lipomatosis

Launois-Bensaude Lipomatosis
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y0598 trans-Chalcone 98.65% 否
HY-RS02711 CIDEA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CIDEA VGNC VGNC:39271
Macaca mulatta CIDEA VGNC VGNC:104219
Rattus norvegicus CIDEA RGD RGD:1305106
Bos taurus CIDEA VGNC VGNC:106691
Mus musculus CIDEA MGD MGI:1270845
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