trans-Chalcone (Synonyms: 反-查耳酮)

目录号: HY-Y0598 纯度: 98.65%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

trans-Chalcone 是从Aronia melanocarpa 果皮中分离出来的，是类黄酮前体的双酚核心结构。trans-Chalcone 是有效的脂肪酸合酶 (FAS) 和 α-淀粉酶 (α-amylase) 抑制剂。trans-Chalcone 引起细胞周期停滞并诱导乳腺癌细胞系 MCF-7 凋亡。trans-Chalcone 具有抗真菌和抗癌活性。

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trans-Chalcone Chemical Structure

CAS No. : 614-47-1

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规格	价格	是否有货
Free Sample (0.1 - 0.2 mg)		Apply now
10 mM * 1 mL in DMSO	￥330	In-stock
5 g	￥300	In-stock
10 g		询价
50 g		询价

or 大包装询价

* Please select Quantity before adding items.

Other Forms of trans-Chalcone:

Chalcone In-stock

trans-Chalcone 相关产品

•相关化合物库:

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•同靶点蛋白产品:

生物活性
纯度 & 产品资料
参考文献

生物活性

trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
2008	IC₅₀	33.4 μM Compound: 17	Cytotoxicity in human OV2008 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human OV2008 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
A2780	IC₅₀	67.5 μM Compound: 17	Cytotoxicity in human A2780 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human A2780 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
A2780	GI₅₀	7.3 μM Compound: Chalcone	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
A549	IC₅₀	> 10 μM Compound: 69	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 35026948]
A549	IC₅₀	> 20 μM Compound: 1	Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay	[PMID: 19883086]
A549	IC₅₀	69.19 μM Compound: Chalcone	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay	[PMID: 32992255]
BT-20	IC₅₀	21.1 μM Compound: 17	Cytotoxicity in human BT20 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human BT20 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
CAL-51	GI₅₀	1.85 μM Compound: SSE14101	Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
CHO	IC₅₀	23 μM Compound: 17	Cytotoxicity in CHO cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in CHO cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
DLD-1	EC₅₀	25 μM Compound: 4	Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
DU-145	IC₅₀	50.1 μM Compound: 17	Cytotoxicity in human DU145 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human DU145 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
Epithelial cell	IC₅₀	> 50 μM Compound: 1	Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay Cytotoxicity against human kidney epithelial cells after 44 hrs by MTT assay	[PMID: 18378360]
FHC	CC₅₀	71 μM Compound: 4	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	EC₅₀	11 μM Compound: 4	Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	GI₅₀	15.7 μM Compound: 18	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 28177228]
HCT-116	GI₅₀	15.7 μM Compound: C1	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 26994844]
HCT-116	GI₅₀	3.96 μM Compound: SSE14101	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HCT-116	EC₅₀	9.5 μM Compound: 4	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HEK293	IC₅₀	10.7 μM Compound: 17	Cytotoxicity in HEK293 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in HEK293 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
HEK293	EC₅₀	11 μM Compound: 5d	Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay	[PMID: 24275249]
HeLa	EC₅₀	> 50000 nM Compound: 2a	Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining	[PMID: 23524161]
HepG2	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22658085]
HK-2	IC₅₀	30.5 μM Compound: 1	Growth inhibition of HK2 cells by sulforhodamine assay Growth inhibition of HK2 cells by sulforhodamine assay	[PMID: 17383189]
HL-60	IC₅₀	55.4 μM Compound: 1	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 25091929]
HT-29	GI₅₀	> 20 μM Compound: Chalcone	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
HT-29	EC₅₀	14 μM Compound: 4	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HT-29	IC₅₀	45.9 μM Compound: Chalcone	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay	[PMID: 32992255]
HT-29	IC₅₀	70 μM Compound: 1	Growth inhibition of HT29 cells by sulforhodamine assay Growth inhibition of HT29 cells by sulforhodamine assay	[PMID: 17383189]
Jurkat	IC₅₀	17.1 μM Compound: 2a	Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 23524161]
K562	IC₅₀	3.8 μM Compound: 2ee	Antiproliferative activity against human K562 cells after 5 days by MTT assay Antiproliferative activity against human K562 cells after 5 days by MTT assay	[PMID: 19837593]
KB	IC₅₀	> 10 μM Compound: 69	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 35026948]
L1210	IC₅₀	> 100 μM Compound: 2a	Cytotoxicity against mouse L1210 cells after 24 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 24 hrs by MTT assay	[PMID: 23524161]
L929	IC₅₀	6.92 μg/mL Compound: 52	Cytotoxicity against mouse L929 cells after 72 hrs by resazurin assay Cytotoxicity against mouse L929 cells after 72 hrs by resazurin assay	[PMID: 22360533]
L929	CC₅₀	89.3 μM Compound: 12	Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31000155]
MCF7	IC₅₀	> 10 μM Compound: 69	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 35026948]
MCF7	GI₅₀	12.4 μM Compound: 18	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 28177228]
MCF7	GI₅₀	12.4 μM Compound: C1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 26994844]
MCF7	IC₅₀	12.6 μM Compound: 17	Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
MCF7	IC₅₀	63 μM Compound: 1	Growth inhibition of MCF7 cells by sulforhodamine assay Growth inhibition of MCF7 cells by sulforhodamine assay	[PMID: 17383189]
MDA-MB-231	IC₅₀	> 10 μM Compound: 69	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 35026948]
MDA-MB-231	IC₅₀	42.8 μM Compound: Chalcone	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay	[PMID: 32992255]
MDA-MB-231	IC₅₀	6.7 μM Compound: 17	Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
MSTO-211H	GI₅₀	8.2 μM Compound: Chalcone	Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
NALM-6	IC₅₀	23.9 μM Compound: 1	Cytotoxicity against human NALM6 cells by MTT assay Cytotoxicity against human NALM6 cells by MTT assay	[PMID: 25091929]
Neutrophil	IC₅₀	13 μM Compound: 12	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
Neutrophil	IC₅₀	27 μM Compound: 12	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
NIH3T3	IC₅₀	> 20 μM Compound: 1a	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay	[PMID: 21112783]
PANC-1	IC₅₀	26 μM Compound: 17	Cytotoxicity in human PANC1 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human PANC1 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]
PBMC	IC₅₀	27 μM Compound: 2a	Cytotoxicity against human PBMC cells after 24 hrs by MTT assay Cytotoxicity against human PBMC cells after 24 hrs by MTT assay	[PMID: 23524161]
Peritoneal macrophage cell	EC₅₀	9.5 μM Compound: 10	Cytotoxicity against BALB/c mouse peritoneal macrophages incubated for 24 hrs by MTT assay Cytotoxicity against BALB/c mouse peritoneal macrophages incubated for 24 hrs by MTT assay	[PMID: 26055530]
TK-10	IC₅₀	42 μM Compound: 1	Growth inhibition of TK10 cells by sulforhodamine assay Growth inhibition of TK10 cells by sulforhodamine assay	[PMID: 17383189]
WM-115	IC₅₀	43.1 μM Compound: 1	Cytotoxicity against human WM115 cells by MTT assay Cytotoxicity against human WM115 cells by MTT assay	[PMID: 25091929]
ZR-75-1	IC₅₀	13.7 μM Compound: 17	Cytotoxicity in human ZR-75-1 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay Cytotoxicity in human ZR-75-1 cells assessed as reduction in cell viability incubated for 68 hrs by MTT assay	[PMID: 28411546]

体外研究
(In Vitro)

trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a K_i of 48 μM^[2].
trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells^[1].
trans-Chalcone (20-80 μM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2^[1].
trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours^[1].
trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC₂₀=30.23 μM; IC₅₀=58.25 μM; IC₈₀=98.03 μM). trans-Chalcone (48 h) has IC₅₀s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	30.23, 58.25, 98.03 μM
Incubation Time:	24 hours
Result:	Induced apoptosis of the breast cancer cell line.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	30.23, 58.25, 98.03 μM
Incubation Time:	24 hours
Result:	Caused cell cycle arrest in G1.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	20, 40, 80 μM
Incubation Time:	24, 48 hours
Result:	Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene. There was marked degradation of cyclin D1 at 48 h.

RT-PCR^[1]

Cell Line:	MCF-7 cell
Concentration:	58.25 μM
Incubation Time:	6, 24 hours
Result:	Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.

分子量

208.26

Formula

C₁₅H₁₂O

CAS 号

614-47-1

性状

固体

颜色

Off-white to light yellow

中文名称

反-查耳酮

结构分类

Flavonoids

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (480.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8017 mL	24.0085 mL	48.0169 mL
5 mM	0.9603 mL	4.8017 mL	9.6034 mL
10 mM	0.4802 mL	2.4008 mL	4.8017 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.00 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.00 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.00 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.65%

选择批次：

Data Sheet (628 KB) SDS (393 KB)

COA (286 KB) HNMR (120 KB) RP-HPLC (252 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Luis Felipe Buso Bortolotto, et al. Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Biomed Pharmacother. 2017 Jan;85:425-433. [Content Brief]

[2]. Mahmoud Najafian, et al. Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase. Mol Biol Rep. 2011 Mar;38(3):1617-20. [Content Brief]

[3]. Tamires Aparecida Bitencourt, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229. [Content Brief]

trans-Chalcone 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8017 mL	24.0085 mL	48.0169 mL	120.0423 mL
	5 mM	0.9603 mL	4.8017 mL	9.6034 mL	24.0085 mL
	10 mM	0.4802 mL	2.4008 mL	4.8017 mL	12.0042 mL
	15 mM	0.3201 mL	1.6006 mL	3.2011 mL	8.0028 mL
	20 mM	0.2401 mL	1.2004 mL	2.4008 mL	6.0021 mL
	25 mM	0.1921 mL	0.9603 mL	1.9207 mL	4.8017 mL
	30 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0014 mL
	40 mM	0.1200 mL	0.6002 mL	1.2004 mL	3.0011 mL
	50 mM	0.0960 mL	0.4802 mL	0.9603 mL	2.4008 mL
	60 mM	0.0800 mL	0.4001 mL	0.8003 mL	2.0007 mL
	80 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5005 mL
	100 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2004 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-Chalcone614-47-1反-查耳酮Fatty Acid Synthase (FASN)ApoptosisFungalα-amylasecyclearrestbreastcancerMCF-7Bcl-2CIDEAAPAF1BAXInhibitorinhibitorinhibit

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trans-Chalcone (Synonyms: 反-查耳酮)

Other Forms of trans-Chalcone:

trans-Chalcone 相关产品

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生物活性

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

trans-Chalcone 相关分类

完整储备液配制表

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trans-Chalcone (Synonyms: 反-查耳酮)

Other Forms of trans-Chalcone:

trans-Chalcone 相关抗体

trans-Chalcone 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

trans-Chalcone 相关抗体:

摩尔计算器

稀释计算器

trans-Chalcone 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

Request for HNMR Report

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