FBXO32 - F-box protein 32 Gene

中文名称：F-box 蛋白 32

种属: Homo sapiens

同用名: Fbx32; MAFbx

基因 ID: 114907 | 基因类型: protein coding

关于 FBXO32

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,497,889-123,541,206 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 28.7), heart (RPKM 22.1) and 18 other tissues.

功能概要

该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质属于 Fbxs 类，含有一个 F-box 结构域。这种蛋白质在肌肉萎缩期间高度表达，而发现缺乏这种基因的小鼠对萎缩有抵抗力。因此，该蛋白质是治疗肌肉萎缩症的潜在药物靶标。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 6 月]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

FBXO32 基因产物(3)

mRNA	Protein	Name
NM_001242463.2	NP_001229392.1	F-box only protein 32 isoform 3
NM_058229.4	NP_478136.1	F-box only protein 32 isoform 1
NM_148177.3	NP_680482.1	F-box only protein 32 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18354498	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	26753747	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	26753747	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	26768247	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

F-box only protein 32

atrogin 1

FBXO32 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FBXO32	Q969P5	EIF3F	Homo sapiens	O00303	IF	18354498
种属内	FBXO32	Q969P5	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	18354498
种属内	FBXO32	Q969P5	EIF3F	Homo sapiens	O00303	Pull Down	18354498

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Muscle Tissue Disease

Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome	AIDS
Acquired Immune Deficiency	Acquired Immunodeficiency
Acquired Immunodeficiency Due To Protein Loss

Muscular Disease

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Myopathy

Muscular Diseases

Myopathies

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04804	FBXO32 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FBXO32	VGNC	VGNC:40774
Bos taurus	FBXO32	VGNC	VGNC:28905
Mus musculus	FBXO32	MGD	MGI:1914981
Macaca mulatta	FBXO32	VGNC	VGNC:72517
Rattus norvegicus	FBXO32	RGD	RGD:620373
Felis catus	FBXO32	VGNC	VGNC:62186

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FBXO32 - F-box protein 32 Gene

关于 FBXO32

功能概要

FBXO32 基因产物(3)

FBXO32 蛋白互作信息

关联疾病

直系同源

热门区域

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FBXO32 - F-box protein 32 Gene

关于 FBXO32

功能概要

FBXO32 基因产物(3)

FBXO32 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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