2. Gene
  3. Adam8 - a disintegrin and metallopeptidase domain 8 Gene

Adam8 - a disintegrin and metallopeptidase domain 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：解整合素和金属肽酶结构域 8

种属: Mus musculus

同用名: MS2; CD156; ADAM 8; CD156a; E430039A18Rik

基因 ID: 11501 | 基因类型: protein coding

关于 Adam8

Chromosome 7: 139,558,845-139,572,475 reverse strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 245 orthologues, 35 paralogues and is associated with 8 phenotypes. Broad expression in ovary adult (RPKM 21.), thymus adult (RPKM 6.6) and 19 other tissues.

功能概要

该基因编码包含解离蛋白和金属蛋白酶结构域的 Adam 蛋白家族成员。编码的蛋白质位于细胞表面，参与细胞外基质的重塑和细胞迁移。缺乏编码蛋白的小鼠在用过敏原治疗后会出现持续性炎症。该基因的可变剪接导致多个变体。 [RefSeq 提供，2015 年 3 月]

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Adam8 基因产物(2)

mRNA Protein Name
NM_001291066.2 NP_001277995.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_007403.3 NP_031429.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
12372841 MGI
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
12135759 MGI
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
12135759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12135759 MGI
enables zinc ion binding IDA
IDA: 通过直接分析推断
12135759 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
19003792 MGI
involved in canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
20683884 MGI
involved in cell morphogenesis IMP
IMP: 通过突变表型推断
11341326 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: 通过直接分析推断
12372841 MGI
involved in leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
20194813 MGI
involved in lymphocyte chemotaxis IDA
IDA: 通过直接分析推断
20856819 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
14761956 MGI
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
20683884 MGI
involved in positive regulation of T cell differentiation in thymus IDA
IDA: 通过直接分析推断
20856819 MGI
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
20194813 MGI
involved in positive regulation of acute inflammatory response IMP
IMP: 通过突变表型推断
21268008 MGI
involved in positive regulation of bone resorption IDA
IDA: 通过直接分析推断
11341326 MGI
involved in positive regulation of bone resorption IMP
IMP: 通过突变表型推断
20683884 MGI
involved in positive regulation of cell adhesion IDA
IDA: 通过直接分析推断
12372841 MGI
involved in positive regulation of cellular extravasation IMP
IMP: 通过突变表型推断
20194813 MGI
involved in positive regulation of eosinophil migration IMP
IMP: 通过突变表型推断
20194813 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
34615811 MGI
involved in positive regulation of fibronectin-dependent thymocyte migration IMP
IMP: 通过突变表型推断
20856819 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
19397475 MGI
involved in positive regulation of innate immune response IDA
IDA: 通过直接分析推断
20683884 MGI
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
14761956 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
20683884 MGI
involved in positive regulation of thymocyte apoptotic process IMP
IMP: 通过突变表型推断
20856819 MGI
involved in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IMP
IMP: 通过突变表型推断
20683884 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of alpha9-beta1 integrin-ADAM8 complex IDA
IDA: 通过直接分析推断
16995821 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12372841 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adam8 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: pfam01562 (26 - 150)

Reprolysin

Reprolysin: pfam01421 (194 - 393)

DISIN

DISIN: smart00050 (410 - 484)

ACR

ACR: smart00608 (486 - 605)

PHA03247

PHA03247: cl33720 (693 - 805)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metalloprotease domain 8

cell surface antigen MS2

macrophage cysteine-rich glycoprotein

重组 Adam8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77558 ADAM8 Protein, Mouse (HEK293, His) Q05910 (P17-S658) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120852 JG26 Inhibitor 98.01% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adam8 NCBI NCBI:101
Macaca mulatta Adam8 NCBI NCBI:100428452
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