2. Gene
  3. ADAM8 - ADAM metallopeptidase domain 8 Gene

ADAM8 - ADAM metallopeptidase domain 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 8

种属: Homo sapiens

同用名: MS2; CD156; CD156a

基因 ID: 101 | 基因类型: protein coding

关于 ADAM8

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,262,423-133,276,868 (from NCBI)

This gene has 11 transcripts (splice variants), 245 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 22.3), spleen (RPKM 13.4) and 12 other tissues.

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。由该基因编码的蛋白质可能参与神经变性过程中的细胞粘附，它被认为是过敏性呼吸系统疾病 (包括哮喘) 的靶点。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 8 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

ADAM8 基因产物(8)

mRNA Protein Name
XR_007061938.1
XM_047424425.1 XP_047280381.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X3
XM_047424423.1 XP_047280379.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X1
NM_001164489.2 NP_001157961.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_001164490.2 NP_001157962.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 3
NM_001109.5 NP_001100.3 disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor
XM_047424424.1 XP_047280380.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X2
XM_047424426.1 XP_047280382.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables immunoglobulin receptor binding IPI
IPI: 通过物理相互作用推断
12777399 GOA
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
12777399 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15574124 GOA
enables tumor necrosis factor receptor superfamily binding IPI
IPI: 通过物理相互作用推断
12777399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
18566576 GOA
involved in inflammatory response IDA
IDA: 通过直接分析推断
12777399 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
15220135 GOA
involved in positive regulation of neutrophil extravasation IDA
IDA: 通过直接分析推断
17548643 GOA
involved in regulation of cell-cell adhesion IDA
IDA: 通过直接分析推断
17548643 GOA
involved in signal release IDA
IDA: 通过直接分析推断
12777399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
17548643 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18397961 GOA
located in dense core granule membrane IDA
IDA: 通过直接分析推断
17548643 GOA
located in phagolysosome IDA
IDA: 通过直接分析推断
17548643 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17548643 GOA
located in podosome IDA
IDA: 通过直接分析推断
15220135 GOA
located in specific granule IDA
IDA: 通过直接分析推断
17548643 GOA
located in tertiary granule IDA
IDA: 通过直接分析推断
17548643 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM8 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (29 - 155)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (200 - 400)

Disintegrin

Disintegrin: Disintegrin (417 - 491)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (494 - 567)

  • 0
  • 200
  • 400
  • 600
  • 824 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metalloproteinase domain 8

cell surface antigen MS2

human leukocyte differentiation antigen

ADAM8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADAM8 P78325 TEC Homo sapiens P42680
Phage Display
25825872
种属内
ADAM8 P78325 TEC Homo sapiens P42680
Peptide Array
25825872
种属内
ADAM8 P78325 NCF1 Homo sapiens P14598
Phage Display
25825872
种属内
ADAM8 P78325 NCF1 Homo sapiens P14598
Peptide Array
25825872
种属内
ADAM8 P78325 FNBP1L Homo sapiens Q5T0N5
Phage Display
25825872
种属内
ADAM8 P78325 FNBP1L Homo sapiens Q5T0N5
Peptide Array
25825872
种属内
ADAM8 P78325 TRIP10 Homo sapiens Q15642
Peptide Array
25825872
种属内
ADAM8 P78325 TRIP10 Homo sapiens Q15642
Phage Display
25825872
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ADAM8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75532 ADAM8 Protein, Human (HEK293, His) AAI15405.1 (I17-P655) ≥95%

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120852 JG26 Inhibitor 98.01% 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADAM8 VGNC VGNC:69494
Mus musculus ADAM8 MGD MGI:107825
Canis familiaris ADAM8 VGNC VGNC:37587
Bos taurus ADAM8 VGNC VGNC:25612
Felis catus ADAM8 VGNC VGNC:59584
Rattus norvegicus ADAM8 RGD RGD:1566394
Others ADAM8 NCBI
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