Adora3 - adenosine A3 receptor Gene

中文名称：腺苷 A3 受体

种属: Mus musculus

同用名: A3R; A3AR; AA3R; ARA3; Gpcr2

关于 Adora3

功能概要

该基因编码一种属于腺苷受体家族的蛋白质，腺苷受体是 G 蛋白偶联受体，参与多种细胞内信号通路和生理功能。由该基因编码的受体在心肌缺血期间介导持续的心脏保护功能，它参与抑制嗜中性粒细胞介导的组织损伤中的嗜中性粒细胞脱颗粒，它与神经保护和神经退行性作用有关，它还可能介导细胞增殖和细胞死亡。该基因与重叠 GeneID:69296 的转录变体共享其 3' 末端外显子，后者编码含有免疫球蛋白结构域的蛋白质。 [RefSeq 提供，2014 年 11 月]

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]