UHRF2 - ubiquitin like with PHD and ring finger domains 2 Gene

中文名称：含 PHD 和无名指结构域泛素样 2

种属: Homo sapiens

同用名: NIRF; URF2; RNF107; TDRD23

关于 UHRF2

功能概要

该基因编码参与细胞周期调节的核蛋白。编码的蛋白质是一种泛素连接酶，能够泛素化 PCNP (含 PEST 的核蛋白) ，它们一起可能在肿瘤发生中发挥作用。编码的蛋白质包含一个 NIRF_N 结构域、一个 PHD 指、一个组和环相关 (SRA) 结构域以及一个 RING 指结构域，其中的几个结构域已被证明对细胞增殖的调节至关重要。这种蛋白质也可能在聚谷氨酰胺聚集体的核内降解中起作用。可变剪接导致多个转录变体，其中一些是非蛋白质编码。[RefSeq 提供，2012 年 2 月]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]