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  3. Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族，成员 2

种属: Mus musculus

同用名: ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2

基因 ID: 11546 | 基因类型: protein coding

关于 Parp2

Chromosome 14: 51,045,298-51,058,758 forward strand.GRCm39:CM001007.3

This gene has 8 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 2.7), liver E14 (RPKM 15.1) and 25 other tissues.

功能概要

该基因编码的蛋白可启动 NAD+ ADP-核糖基转移酶活性。作用于碱基切除修复和外在凋亡信号通路的上游或内部。位于核仁和核质中。以多种结构表达，包括中枢神经系统；性腺;肝;视网膜；和胸腺。与人类 PARP2（聚（ADP-核糖）聚合酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 基因产物(1)

mRNA Protein Name
NM_009632.3 NP_033762.1 poly [ADP-ribose] polymerase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
10364231 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11948190 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within base-excision repair IMP
IMP: 通过突变表型推断
11948190 MGI
involved in decidualization IMP
IMP: 通过突变表型推断
34580230 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
12065591 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
15615785 MGI
located in nucleoplasm IDA
IDA: 通过直接分析推断
15615785 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12065591 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Parp2 蛋白结构

PLN03124

PLN03124: cl33640 (26 - 554)

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  • 559 a.a.
蛋白主名 其他名称

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase) 2

ADP-ribosyltransferase diphtheria toxin-like 2

DNA ADP-ribosyltransferase PARP2

NAD(+) ADP-ribosyltransferase 2

poly[ADP-ribose] synthase 2

poly[ADP-ribose] synthetase 2

protein poly-ADP-ribosyltransferase PARP2

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10162 Olaparib Inhibitor 99.98% 是
HY-16106 Talazoparib Inhibitor 99.89% 否
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10617A Rucaparib Inhibitor 99.97% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.41% 是
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
HY-102003A Rucaparib camsylate Inhibitor / 否
HY-10617C Rucaparib tartrate Inhibitor / 否
HY-10617D Rucaparib acetate Inhibitor / 否
HY-10617B Rucaparib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-122661 Mefuparib hydrochloride Inhibitor 98.94% Phase 4
HY-10129 Veliparib Inhibitor 99.92% Phase 3
HY-10130 Veliparib dihydrochloride Inhibitor 99.96% Phase 3
HY-132167 Saruparib Inhibitor 99.79% Phase 2
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-137457A Venadaparib hydrochloride Inhibitor / Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-13688A PJ34 Inhibitor 98.11% 否
HY-13990 NVP-TNKS656 Inhibitor 99.66% 否
HY-13688 PJ34 hydrochloride Inhibitor 99.91% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-14478 UPF 1069 Inhibitor 99.10% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-100225 ME0328 Inhibitor 99.64% 否
HY-137457 Venadaparib Inhibitor 98.11% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-18954 NMS-P118 Inhibitor 99.78% 否
HY-19351 MN-64 Inhibitor 99.61% 否
HY-156419 PARP7-IN-16 Inhibitor 99.91% 否
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% 否
HY-10614 A-966492 Inhibitor 99.95% 否
HY-108632 BYK204165 Inhibitor 98.66% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-156419A PARP7-IN-16 free base Inhibitor / 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-149800 PARP-1-IN-3 Inhibitor 99.30% 否
HY-105692 DR2313 Inhibitor 99.66% 否
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.43% 否
HY-102035 PARP-2-IN-1 Inhibitor 99.56% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-132297 PARP1-IN-5 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-W294889 OUL245 Inhibitor / 否
HY-105253 PARP-2/1-IN-2 Inhibitor / 否
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / 否
HY-100847 AZ0108 Inhibitor / 否
HY-145749 PARPYnD Inhibitor / 否
HY-161606 PARP-1/2/7-IN-1 Inhibitor / 否
HY-151625 PARP-2-IN-3 Inhibitor / 否
HY-14477 UPF-1035 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parp2 NCBI NCBI:10038
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