2. Gene
  3. PARP2 - poly(ADP-ribose) polymerase 2 Gene

PARP2 - poly(ADP-ribose) polymerase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶 2

种属: Homo sapiens

同用名: ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2

基因 ID: 10038 | 基因类型: protein coding

关于 PARP2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,343,635-20,357,904 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码聚 (ADP-核糖基) 转移酶样 2 蛋白，它包含一个催化结构域，能够催化聚 (ADP-核糖基) 化反应。该蛋白质具有与聚 (ADP-核糖基) 转移酶同源的催化结构域，但缺少激活聚 (ADP-核糖基) 转移酶 C 末端催化结构域的 N 末端 DNA 结合结构域。该蛋白质 N 末端区域内的碱性残基可能具有潜在的 DNA 结合特性，并且可能参与该蛋白质的核和/或核仁靶向。已发现编码不同同种型的两种选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

PARP2 基因产物(5)

mRNA Protein Name
NM_005484.4 NP_005475.2 poly [ADP-ribose] polymerase 2 isoform 1
XM_005267247.4 XP_005267304.1 poly [ADP-ribose] polymerase 2 isoform X1
XM_047430869.1 XP_047286825.1 poly [ADP-ribose] polymerase 2 isoform X3
XM_017020912.2 XP_016876401.1 poly [ADP-ribose] polymerase 2 isoform X2
NM_001042618.2 NP_001036083.1 poly [ADP-ribose] polymerase 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD DNA ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
27471034 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
30104678 GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein-serine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
28190768 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
32939087 GOA
enables damaged DNA binding IDA
IDA: 通过直接分析推断
34108479 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
32939087 GOA
enables poly-ADP-D-ribose binding IDA
IDA: 通过直接分析推断
30104678 GOA
enables poly-ADP-D-ribose modification-dependent protein binding IDA
IDA: 通过直接分析推断
30104678 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21812934 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA ADP-ribosylation IDA
IDA: 通过直接分析推断
27471034 GOA
involved in DNA damage response IDA
IDA: 通过直接分析推断
34108479 GOA
involved in DNA repair IDA
IDA: 通过直接分析推断
30104678 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: 通过直接分析推断
32939087 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
32939087 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: 通过直接分析推断
25043379 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
15615785 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
15615785 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26704974 GOA
is active in site of DNA damage IDA
IDA: 通过直接分析推断
30104678 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
26704974 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP2 蛋白结构

WGR

WGR: WGR domain (112 - 194)

PARP_reg

PARP_reg: Poly(ADP-ribose) polymerase, regulatory domain (231 - 363)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (365 - 577)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 583 a.a.
蛋白主名 其他名称

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+

poly(ADP-ribose) polymerase)-like 2

ADP-ribosyltransferase diphtheria toxin-like 2

ADPRT-2

DNA ADP-ribosyltransferase PARP2

NAD(+) ADP-ribosyltransferase 2

hPARP-2

poly (ADP-ribose) polymerase family, member 2

poly (ADP-ribosyl) transferase-like 2

poly[ADP-ribose] synthase 2

poly[ADP-ribose] synthetase 2

protein poly-ADP-ribosyltransferase PARP2

PARP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PARP2 Q9UGN5 FKBP3 Homo sapiens Q00688
Protein Array
21812934
Intra PARP2 Q9UGN5 FKBP3 Homo sapiens Q00688
Enzymatic Study
21812934
Intra PARP2 Q9UGN5 APLF Homo sapiens Q8IW19
Protein Array
21812934
Intra PARP2 Q9UGN5 HMGN2 Homo sapiens P05204
Protein Array
21812934
Intra PARP2 Q9UGN5 STAC Homo sapiens Q99469
Enzymatic Study
21812934
Intra PARP2 Q9UGN5 STAC Homo sapiens Q99469
Protein Array
21812934
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Fallopian Tube Carcinoma

Fallopian Tube Cancer

Cancer Of The Fallopian Tube

Carcinoma Of Fallopian Tube

Neoplasm Of Fallopian Tube

Fallopian Tube Neoplasms

Fallopian Tube Ca

Fallopian Tube Neoplasm

Malignant Neoplasm Of Uterine Tube

Malignant Tumor Of Fallopian Tube

Malignant Tumour Of Fallopian Tube

Tumor Of The Fallopian Tube

Tumor, Fallopian Tube, Malignant

Malignant Tumor Of Fallopian Tubes

Cancer Of Fallopian Tubes

Malignant Tubal Tumor

Tubal Cancer

Malignant Neoplasm Of Fallopian Tube

Primary Malignant Neoplasm Of Fallopian Tube

Cancer Of The Oviduct
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Fallopian Tube Disease

Fallopian Tube Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10162 Olaparib Inhibitor 99.98% 是
HY-16106 Talazoparib Inhibitor 99.89% 否
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10617A Rucaparib Inhibitor 99.97% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.41% 是
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
HY-102003A Rucaparib camsylate Inhibitor / 否
HY-10617C Rucaparib tartrate Inhibitor / 否
HY-10617D Rucaparib acetate Inhibitor / 否
HY-10617B Rucaparib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-122661 Mefuparib hydrochloride Inhibitor 98.94% Phase 4
HY-10129 Veliparib Inhibitor 99.78% Phase 3
HY-10130 Veliparib dihydrochloride Inhibitor 99.98% Phase 3
HY-132167 Saruparib Inhibitor 99.76% Phase 2
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-137457A Venadaparib hydrochloride Inhibitor / Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-13688A PJ34 Inhibitor 98.11% 否
HY-13990 NVP-TNKS656 Inhibitor 99.66% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-13688 PJ34 hydrochloride Inhibitor 99.91% 否
HY-14478 UPF 1069 Inhibitor 99.10% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-100225 ME0328 Inhibitor 99.64% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-137457 Venadaparib Inhibitor 98.11% 否
HY-19351 MN-64 Inhibitor 99.61% 否
HY-18954 NMS-P118 Inhibitor 99.78% 否
HY-156419 PARP7-IN-16 Inhibitor 99.91% 否
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% 否
HY-108632 BYK204165 Inhibitor 98.66% 否
HY-10614 A-966492 Inhibitor 99.95% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-156419A PARP7-IN-16 free base Inhibitor / 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-149800 PARP-1-IN-3 Inhibitor 99.30% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-105692 DR2313 Inhibitor 99.66% 否
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.43% 否
HY-102035 PARP-2-IN-1 Inhibitor 99.56% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-132297 PARP1-IN-5 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-W294889 OUL245 Inhibitor / 否
HY-105253 PARP-2/1-IN-2 Inhibitor / 否
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / 否
HY-100847 AZ0108 Inhibitor / 否
HY-145749 PARPYnD Inhibitor / 否
HY-161606 PARP-1/2/7-IN-1 Inhibitor / 否
HY-151625 PARP-2-IN-3 Inhibitor / 否
HY-14477 UPF-1035 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PARP2 VGNC VGNC:53577
Felis catus PARP2 VGNC VGNC:80893
Rattus norvegicus PARP2 RGD RGD:1310568
Macaca mulatta PARP2 VGNC VGNC:84417
Canis familiaris PARP2 VGNC VGNC:54219
Mus musculus PARP2 MGD MGI:1341112
Others PARP2 NCBI
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